{"id":61630,"date":"2018-03-09T22:49:29","date_gmt":"2018-03-09T22:49:29","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-y-desarrollo-de-un-programa-de-seguimiento-integral-de-pacientes-vih-monitorizacion-y-atencion-farmaceutica\/"},"modified":"2018-03-09T22:49:29","modified_gmt":"2018-03-09T22:49:29","slug":"diseno-y-desarrollo-de-un-programa-de-seguimiento-integral-de-pacientes-vih-monitorizacion-y-atencion-farmaceutica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/evaluacion-de-farmacos\/diseno-y-desarrollo-de-un-programa-de-seguimiento-integral-de-pacientes-vih-monitorizacion-y-atencion-farmaceutica\/","title":{"rendered":"Dise\u00f1o y desarrollo de un programa de seguimiento integral de pacientes vih+: monitorizaci\u00f3n y atenci\u00f3n farmac\u00e9utica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Salvador Enrique Cabrera Figueroa <\/strong><\/h2>\n<p>El estudio ha abordado el dise\u00f1o y desarrollo de un programa de seguimiento integral de pacientes vih+, que incluye actividades de atenci\u00f3n farmac\u00e9utica y monitorizaci\u00f3n de concentraciones plasm\u00e1ticas de antirretrovirales. Las etapas realizadas comprenden: -la puesta a punto y validaci\u00f3n, de acuerdo a las normas establecidas por la fda, de una t\u00e9cnica anal\u00edtica por hplc para la  determinaci\u00f3n de los antirretrovirales: atazanavir, efavirenz, indinavir, lopinavir, nelfinavir, ritonavir y saquinavir en plasma sangu\u00edneo. -la optimizaci\u00f3n de los tratamientos con f\u00e1rmacos antirretrovirales. Se ha detectado una tasa importante de pacientes con problemas de adherencia (38% de los evaluados), lo que ha dado lugar a actuaciones de educaci\u00f3n del paciente y a la aplicaci\u00f3n de t\u00e9cnicas de refuerzo positivo para mejorarla. -el desarrollo de un modelo farmacocin\u00e9tico poblacional de efavirenz en 241 pacientes con 814 concentraciones procedentes de la monitorizaci\u00f3n en pacientes vih+ usando un modelo no lineal de efectos mixtos (nonmem). -el an\u00e1lisis de la influencia sobre el aclaramiento plasm\u00e1tico de efavirenz del sexo, edad, peso, altura, tratamiento antirretroviral y asociaci\u00f3n con rifampicina, fenobarbital, fenito\u00edna y metadona. Cuando se asocian estos f\u00e1rmacos, el aclaramiento plasm\u00e1tico de efavirenz se incrementa por 1,70; 1,54; 1,18 y 1,21 respectivamente. No obstante, la baja presencia de estas variables no permitieron su inclusi\u00f3n en el modelo poblacional -el genotipado de un grupo de 32 pacientes ha demostrado que el polimorfismo gen\u00e9tico del cyp2b6, provoca en un 80% de los pacientes deficientes metabolizadores (g\/t y t\/t) un descenso del aclaramiento plasm\u00e1tico de efavirenz.  se ha demostrado que el programa de seguimiento integral de los pacientes con vih representa una importante contribuci\u00f3n en la mejora de los resultados cl\u00ednicos, y que la optimizaci\u00f3n de las dosis contribuye a mejorar la efectividad cl\u00ednica y la calidad de vida relacionada con la salud de estos pacientes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o y desarrollo de un programa de seguimiento integral de pacientes vih+: monitorizaci\u00f3n y atenci\u00f3n farmac\u00e9utica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o y desarrollo de un programa de seguimiento integral de pacientes vih+: monitorizaci\u00f3n y atenci\u00f3n farmac\u00e9utica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Salvador Enrique Cabrera Figueroa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/11\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aa Jos\u00e9 Garc\u00eda S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rogelio Gonzalez sarmiento <\/li>\n<li>Miguel angel del Pozo barriuso (vocal)<\/li>\n<li>Carlos Codina jane (vocal)<\/li>\n<li>diego Tejedor hernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Salvador Enrique Cabrera Figueroa El estudio ha abordado el dise\u00f1o y desarrollo de un programa de seguimiento [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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