{"id":61784,"date":"2007-10-12T00:00:00","date_gmt":"2007-10-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/somatostatina-y-cortistatina-en-la-retinopata%c2%ada-diabetica-analisis-en-humor-va%c2%adtreo-y-estudio-de-expresion-y-localizacion-en-retina\/"},"modified":"2007-10-12T00:00:00","modified_gmt":"2007-10-12T00:00:00","slug":"somatostatina-y-cortistatina-en-la-retinopata%c2%ada-diabetica-analisis-en-humor-va%c2%adtreo-y-estudio-de-expresion-y-localizacion-en-retina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/hormonas\/somatostatina-y-cortistatina-en-la-retinopata%c2%ada-diabetica-analisis-en-humor-va%c2%adtreo-y-estudio-de-expresion-y-localizacion-en-retina\/","title":{"rendered":"Somatostatina y cortistatina en la retinopat\u00edadiab\u00e9tica: an\u00e1lisis en humor v\u00edtreo y estudio de expresi\u00f3n y localizaci\u00f3n en retina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esther Carrasco De Miguel <\/strong><\/h2>\n<p>La retinopat\u00eda diab\u00e9tica (rd) es la principal causa de ceguera en la poblaci\u00f3n en edad laboral en los pa\u00edses industrializados. Podemos distinguir dos grandes entidades como responsables de la p\u00e9rdida de visi\u00f3n en los pacientes diab\u00e9ticos: la retinopat\u00eda diab\u00e9tica proliferativa (rdp, m\u00e1s frecuente en la diabetes mellitus tipo 1) y el edema macular (em, m\u00e1s frecuente en la diabetes mellitus tipo 2). En su etiopatogenia, intervienen tanto la hiperglucemia como las v\u00edas metab\u00f3licas directamente relacionadas con ella, tales como la v\u00eda de los polioles, la activaci\u00f3n de la pkc, la v\u00eda de las hexosaminas, el incremento de radicales libres y el ac\u00famulo de los productos de glicosilaci\u00f3n avanzada (ages). La activaci\u00f3n de estas v\u00edas metab\u00f3licas producir\u00e1 una serie de alteraciones en la retina neural (degeneraci\u00f3n neuroretiniana) y lesionar\u00e1 el lecho capilar situado en la retina interna (lesi\u00f3n microangiop\u00e1tica). En etapas finales, se formar\u00e1n neovasos que tienen tropismo hacia el cuerpo v\u00edtreo, donde se anclan y pueden producir un desprendimiento de la retina. Adem\u00e1s, dada su fragilidad, pueden sangrar y ocasionar hemorragias masivas en el interior del humor v\u00edtreo. Para que proliferen los neovasos es fundamental que exista hiperexpresi\u00f3n de una serie de factores denominados factores angiog\u00e9nicos, entre los que cabe destacar el factor de crecimiento del endotelio vascular (vegf). Estos factores angiog\u00e9nicos est\u00e1n contrarrestados por factores antiangiog\u00e9nicos, entre los que destaca el factor derivado del epitelio pigmentario (pedf). Por tanto, en realidad ser\u00e1 el balance entre los factores angiog\u00e9nicos y los antiangiog\u00e9nicos el que determinar\u00e1 si va a producirse o no la formaci\u00f3n de neovasos. Los factores antiangiog\u00e9nicos, y especialmente el pedf, se encuentran en abundantes concentraciones en el humor v\u00edtreo a fin de preservarlo libre de neovasos y evitar el avance de cualquier estructura vascular hacia su interior. la investigaci\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Somatostatina y cortistatina en la retinopat\u00edadiab\u00e9tica: an\u00e1lisis en humor v\u00edtreo y estudio de expresi\u00f3n y localizaci\u00f3n en retina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Somatostatina y cortistatina en la retinopat\u00edadiab\u00e9tica: an\u00e1lisis en humor v\u00edtreo y estudio de expresi\u00f3n y localizaci\u00f3n en retina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esther Carrasco De Miguel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael Sim\u00f3 Canonge<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Xavier Par\u00e9s Casasampera <\/li>\n<li>Ram\u00f3n Deulofeu Piquet (vocal)<\/li>\n<li>Roser Casamitjana Abella (vocal)<\/li>\n<li>Enric Esmatjes Mompo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esther Carrasco De Miguel La retinopat\u00eda diab\u00e9tica (rd) es la principal causa de ceguera en la poblaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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