{"id":61806,"date":"2007-10-12T00:00:00","date_gmt":"2007-10-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/role-of-epigenetic-modifications-in-acute-promyelocytic-leukemia\/"},"modified":"2007-10-12T00:00:00","modified_gmt":"2007-10-12T00:00:00","slug":"role-of-epigenetic-modifications-in-acute-promyelocytic-leukemia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/role-of-epigenetic-modifications-in-acute-promyelocytic-leukemia\/","title":{"rendered":"Role of epigenetic modifications in acute promyelocytic leukemia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raffaella Villa <\/strong><\/h2>\n<p>Role of epigenetic modifications in acute promyelocytic leukemia #resumen: mi trabajo ha estado enfocado en la implicaci\u00f3n de los diferentes mecanismos epigen\u00e9ticos de pml-rara en la inducci\u00f3n de la leucemia promielocitica aguda (apl).En particular yo estudi\u00e9 el rol de mbdl, un miembro de la conservada familia de proteinas capaces de unirse al dna metilado, demostrando que desempe\u00f1a un papel importante en la progresi\u00f3n de la leucemia. De hecho, mostr\u00e9 que mbdl es recruida por pml-rara a sus promotores diana a trav\u00e9s de los mecanismos mediados por hdac3, participando por tanto en la represi\u00f3n transen\u00bbpcional. Adem\u00e1s, investigu\u00e9 hasta donde la metilaci\u00f3n de la h3k27 mediada por polycomb contribuye a la tumorg\u00e9nesis mediada por pml-rara. Demostr\u00e9 que pml-rara dirige al prc2 hacia el locus del tumor supresor causando la metilaci\u00f3n de la h3k27. Fue interesante ser capaz de mostrar que tanto la metilaci\u00f3n del dna como la de las histonas era requerida para mantener el aberrante silencio g\u00e9nico. Esto apuntaba hacia una intercomunicaci\u00f3n entre estos diferentes marcadores epigen\u00e9ticos contribuyendo a la patolog\u00eda molecular de la leucemia. Resumiendo, estos resultados nos proporcionan elementos nuevos para comprender los mecanismos moleculares esenciales en la tumorg\u00e9nesis y progresi\u00f3n de la apl.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Role of epigenetic modifications in acute promyelocytic leukemia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Role of epigenetic modifications in acute promyelocytic leukemia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raffaella Villa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luciano Di Croce<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: ferran Azorin marin <\/li>\n<li>fran\u00ed\u00a7ois Fuks (vocal)<\/li>\n<li>Miguel angel Vidal caballero (vocal)<\/li>\n<li>salvador Aznar benitah (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raffaella Villa Role of epigenetic modifications in acute promyelocytic leukemia #resumen: mi trabajo ha estado enfocado en 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