{"id":61828,"date":"2007-11-12T00:00:00","date_gmt":"2007-11-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cuantificacion-de-arnm-y-expresion-proteica-de-las-subunidades-alfa-y-beta-de-canales-de-potasio-que-intervienen-en-la-corriente-de-polarizacion-ik-durante-la-cardiogenesis\/"},"modified":"2007-11-12T00:00:00","modified_gmt":"2007-11-12T00:00:00","slug":"cuantificacion-de-arnm-y-expresion-proteica-de-las-subunidades-alfa-y-beta-de-canales-de-potasio-que-intervienen-en-la-corriente-de-polarizacion-ik-durante-la-cardiogenesis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/cuantificacion-de-arnm-y-expresion-proteica-de-las-subunidades-alfa-y-beta-de-canales-de-potasio-que-intervienen-en-la-corriente-de-polarizacion-ik-durante-la-cardiogenesis\/","title":{"rendered":"Cuantificacion de arnm y expresion proteica de las subunidades alfa y beta de canales de potasio que intervienen en la corriente de polarizacion ik durante la cardiogenesis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Pilar De Castro Garcia <\/strong><\/h2>\n<p>La presente tesis doctoral aborda el analisis de la expresion de las subunidades alfa y beta de diversos canales ionicos de sodio, potasio y calcio en distintas fases del desarrollo embrionario. La hipotesis de trabajo es novedosa y la metodolog\u00eda utilizada para llevar a cabo la experimentacion es sofisticada. Los resultado obtenidos con los 4 estudios que se incluyen en el apartado de resultados demuestran por promera vez: 1) los patrones de expresion de las subunidades alfa kcnq1, kcnh2, y beta kcne3 en distintos tejidos y en distintos estadios del desarrollo embrionario asi como en ratones adultos. 2) la distinta expresion de las subunidades beta kcne1-5 en tejido auricular respecto al ventricular, lo que justificaria diferencias en la expresion de las corrientes ionicas generados por los canales k formados por las subunidades kcnq1 y kcnqh2, a pesar de que el patron de expresion de estas subunidades alfa es similar en la auricula y en ventriculo. 3) la localizacion de las distintas unidades alfa kcnq1 y kcnh2 y beta kcne1-3 dentro de la celula cardiaca, lo que premite profundizar en el conocimiento de las interacciones y la regulacion de los canales ionicos de potasio en la celulas cardiacas. 4) la distinta modulacion de la expresion de canales ionicos de sodio, calcio y potasio por parte de la proteina morfogenica osea (bmp10). La ausencia de bmp10 en el raton conduce a una dismuncion en las unidades alfa de los canales de sodio (scna5) y de potasio (kcnh2), sin modificar la de calcio (cacnac1). Por el contrario, la sobreexpresion de bmp10 aumental expresion del arnm para la subunidad cacnac1.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cuantificacion de arnm y expresion proteica de las subunidades alfa y beta de canales de potasio que intervienen en la corriente de polarizacion ik durante la cardiogenesis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cuantificacion de arnm y expresion proteica de las subunidades alfa y beta de canales de potasio que intervienen en la corriente de polarizacion ik durante la cardiogenesis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Pilar De Castro Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Ja\u00e9n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Diego Franco Jaime<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: virginio Garc\u00eda mart\u00ednez <\/li>\n<li>ricardo Caballero collado (vocal)<\/li>\n<li>ramon Mu\u00f1oz-chapuli oriol (vocal)<\/li>\n<li>marine Campione (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Pilar De Castro Garcia La presente tesis doctoral aborda el analisis de la expresion de las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,18923],"tags":[7940,136553,136555,7945,136554,55262],"class_list":["post-61828","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-jaen","tag-diego-franco-jaime","tag-maria-pilar-de-castro-garcia","tag-marine-campione","tag-ramon-munoz-chapuli-oriol","tag-ricardo-caballero-collado","tag-virginio-garcia-Martinez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/61828","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=61828"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/61828\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=61828"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=61828"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=61828"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}