{"id":61851,"date":"2007-12-12T00:00:00","date_gmt":"2007-12-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-colesterol-en-la-esteatohepatitis-no-alcoholica\/"},"modified":"2007-12-12T00:00:00","modified_gmt":"2007-12-12T00:00:00","slug":"papel-del-colesterol-en-la-esteatohepatitis-no-alcoholica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia\/papel-del-colesterol-en-la-esteatohepatitis-no-alcoholica\/","title":{"rendered":"Papel del colesterol en la esteatohepatitis no alcoholica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Caballero Gonzalez <\/strong><\/h2>\n<p>La enfermedad del h\u00edgado graso no alcoh\u00f3lico est\u00e1 aumentando en los \u00faltimos a\u00f1os en los pa\u00edses occidentales debido al cambio en los h\u00e1bitos de alimentaci\u00f3n y la vida sedentaria. El primer estadio de la enfermedad es el h\u00edgado graso o esteatosis, d\u00f3nde se produce un aumento de grasa en los hepatocitos. Este estado de la enfermedad es benigno y reversible, pero puede progresar a un estado de la enfermedad m\u00e1s avanzada como es la esteatohepatitis, d\u00f3nde adem\u00e1s de grasa en el hepatocito se producen procesos de muerte hepatocelular, necrosis y apoptosis, e inflamaci\u00f3n y fibrosis, y que puede finalizar en estadios finales de la enfermedad como la cirrosis, y hepatocarcinoma. No est\u00e1 claro porqu\u00e9 algunos pacientes con esteatosis desarrollan esteatohepatitis mientras que otros no. En este punto es importante conocer los mecanismos por los cuales un h\u00edgado graso evoluciona a esteatohepatitis para localizar dianas terap\u00e9uticas para l tratamiento. En este trabajo mediante modelos nutricionales y gen\u00e9ticos se estudia el papel del colesterol en la progresi\u00f3n de la progresi\u00f3n de la enfermedad a esteatohepatitis. Los resultados del trabajo muestran como la acumulaci\u00f3n de colesterol libre en la membrana de las mitocondrias de los hepatocitos produce una disminuci\u00f3n de la fluidez mitocondrial, provocando una disminuci\u00f3n del transporte de glutati\u00f3n a la mitocondria. Esta disminuci\u00f3n del glutati\u00f3n mitocondrial produce una mayor producci\u00f3n de radicales libres en la mitocondria al exponer a los hepatocitos a citoquinas como el tnf, produci\u00e9ndose una aumento en la muerte hepatocelular. Adem\u00e1s el tratamiento con atorvastatina, un inhibidor de la s\u00edntesis de colesterol en un modelo gen\u00e9tico de obesidad como son los ratones ob\/ob, los cuales tienen un aumento en los niveles de colesterol, una disminuci\u00f3n de la fluidez de membrana mitocondrial y una disminuci\u00f3n en los niveles de glutati\u00f3n mitocondrial, produce un aumento en la fluidez de membrana mitocondrial y una normalizaci\u00f3n de los niveles de glutati\u00f3n mitocondrial, protegiendo a estos hepatocitos a la muerte celular producida por el  tnf.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del colesterol en la esteatohepatitis no alcoholica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del colesterol en la esteatohepatitis no alcoholica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Caballero Gonzalez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Garcia Ruiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: xavier Par\u00e9s casampera <\/li>\n<li>pablo Garc\u00eda de frutos (vocal)<\/li>\n<li>ramon Bataller alberola (vocal)<\/li>\n<li>conchi Mora giral (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Caballero Gonzalez La enfermedad del h\u00edgado graso no alcoh\u00f3lico est\u00e1 aumentando en los \u00faltimos a\u00f1os en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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