{"id":61869,"date":"2018-03-09T22:49:44","date_gmt":"2018-03-09T22:49:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-de-los-sistemas-de-transduccion-de-senal-en-el-sa%c2%adndrome-de-down-estudio-en-cerebro-humano-y-en-el-modelo-murino-ts65dn\/"},"modified":"2018-03-09T22:49:44","modified_gmt":"2018-03-09T22:49:44","slug":"alteraciones-de-los-sistemas-de-transduccion-de-senal-en-el-sa%c2%adndrome-de-down-estudio-en-cerebro-humano-y-en-el-modelo-murino-ts65dn","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacologia\/alteraciones-de-los-sistemas-de-transduccion-de-senal-en-el-sa%c2%adndrome-de-down-estudio-en-cerebro-humano-y-en-el-modelo-murino-ts65dn\/","title":{"rendered":"Alteraciones de los sistemas de transducci\u00f3n de se\u00f1al en el s\u00edndrome de down: estudio en cerebro humano y en el modelo murino ts65dn."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lumbreras Fernandez De Nograro Mar\u00eda  Angeles <\/strong><\/h2>\n<p>El s\u00edndrome de down (sd) producido por la trisom\u00eda del cromosoma 21, es la causa gen\u00e9tica m\u00e1s frecuente que origina retraso mental. En las autopsias de individuos en torno a los 40 a\u00f1os es caracter\u00edstica la prematura aparici\u00f3n de neuropatolog\u00eda similar a la que aparece en la enfermedad de alzheimer. El trabajo de investigaci\u00f3n realizado ha profundizado en los mecanismos moleculares que pueden explicar la disfunci\u00f3n intelectual, y se han descrito alteraciones funcionales de dos de las principales v\u00edas de transducci\u00f3n de la se\u00f1al nerviosa que se relacionan con la plasticidad en las \u00e1reas cerebrales involucradas en el aprendizaje y la memoria: las v\u00edas de tranducci\u00f3n a trav\u00e9s de adenilato ciclasa (ac) y de fosfolipasa c (plc). Se analizaron en el modelo murino tris\u00f3mico ts65dn, determin\u00e1ndose que la actividad basal ac y su estimulaci\u00f3n por forskolina est\u00e1 severamente disminuida en los ts65dn en corteza e hipocampo, pero no en cerebelo. Por tanto, la trisom\u00eda afecta diferencialmente a las isoformas de ac y de hecho, en el hipocampo del ts65dn, la isoforma ac i presenta una disminuci\u00f3n del 31% respecto al control. Sin embargo, \u00fanicamente existen deficiencias funcionales a trav\u00e9s de plcb en el cerebelo de ts65dn, donde la isoforma plcb4 presenta niveles de expresi\u00f3n un 30% inferiores a controles. En humanos, se observa que la producci\u00f3n basal de ampc est\u00e1 reducida en conrteza cerebral de sd pero no en ea. La estimulaci\u00f3n con gtpys, noradrenalina, skf38393 y forskolina est\u00e1 afectada negativamente en corteza de sd y ea, siendo en los cerebros sd inferior que en ea. En el cerebelo la actividad basal y con forskolina en sd y ea no se diferencian entre s\u00ed, pero est\u00e1n disminuidas respeto a los cerebelos controles. La respuesta plc basal y en presencia del i\u00f3n calcio est\u00e1 consevada tanto en corteza como en cerebelo de sd y ea. Tanto la ac como la plcb, principales rutas que intervienen en el almacenamiento de la informaci\u00f3n neuronal, est\u00e1n est<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones de los sistemas de transducci\u00f3n de se\u00f1al en el s\u00edndrome de down: estudio en cerebro humano y en el modelo murino ts65dn.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones de los sistemas de transducci\u00f3n de se\u00f1al en el s\u00edndrome de down: estudio en cerebro humano y en el modelo murino ts65dn. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lumbreras Fernandez De Nograro Mar\u00eda  Angeles <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jes\u00fas Florez Beledo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  amor Hurle  gonzalez <\/li>\n<li>Manuel Megias pacheco (vocal)<\/li>\n<li> Martinez-cue pesini carmen (vocal)<\/li>\n<li> Lopez de Jes\u00fas  maider (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lumbreras Fernandez De Nograro Mar\u00eda Angeles El s\u00edndrome de down (sd) producido por la trisom\u00eda del cromosoma [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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