{"id":6187,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/relaciones-estructura-inmunogenicidad-en-el-alergeno-principal-de-la-mostaza\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"relaciones-estructura-inmunogenicidad-en-el-alergeno-principal-de-la-mostaza","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/relaciones-estructura-inmunogenicidad-en-el-alergeno-principal-de-la-mostaza\/","title":{"rendered":"Relaciones estructura-inmunogenicidad en el alergeno principal de la mostaza."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Angel Gonzalez De La Pe\u00f1a <\/strong><\/h2>\n<p>Se ha amplificado mediante pcr la secuencia genomica que codifica el alergeno sin a 1. Siete clones han sido analizados, y uno de ellos se utilizo en la realizacion de diversas construcciones de expresion en e. Coli. La construccion llevada a cabo en el plasmido pgex-2t expresa la proteina recombinante en forma de proteina de fusion con la glutation s-transferasa. Mediante esta construccion se ha logrado aislar el alergeno recombinante en forma soluble (rsinal).  se ha caracterizado inmunologicamente a rsinal, empleando para ello suero policlonal de conejo, anticuerpos monoclonales y sueros de pacientes alergicos a mostaza.  asimismo, se ha comprobado su resistencia a la digestion con tripsina. En todos los ensayos realizados, rsinal mostro un comportamiento virtualmente identico al alergeno nativo.  finalmente, se han llevado a cabo estudios de reactividad cruzada entre sin a 1 y las napinas de colza, las cuales son descritas como alergenos por vez primera en el presente trabajo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Relaciones estructura-inmunogenicidad en el alergeno principal de la mostaza.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Relaciones estructura-inmunogenicidad en el alergeno principal de la mostaza. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Angel Gonzalez De La Pe\u00f1a <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rosalia Rodriguez Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Gregorio Gavilanes Franco <\/li>\n<li>Manuel Martin Esteban (vocal)<\/li>\n<li>Ignacio Moneo Goiri (vocal)<\/li>\n<li>Gabriel Salcedo Dur\u00e1n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Angel Gonzalez De La Pe\u00f1a Se ha amplificado mediante pcr la secuencia genomica que codifica el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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