{"id":61909,"date":"2018-03-09T22:49:48","date_gmt":"2018-03-09T22:49:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-determinantes-de-la-respuesta-terapeutica-en-pacientes-afectos-de-hepattitis-cronica-por-la-infeccion-de-l-virus-de-la-hepatitis-c\/"},"modified":"2018-03-09T22:49:48","modified_gmt":"2018-03-09T22:49:48","slug":"factores-determinantes-de-la-respuesta-terapeutica-en-pacientes-afectos-de-hepattitis-cronica-por-la-infeccion-de-l-virus-de-la-hepatitis-c","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/factores-determinantes-de-la-respuesta-terapeutica-en-pacientes-afectos-de-hepattitis-cronica-por-la-infeccion-de-l-virus-de-la-hepatitis-c\/","title":{"rendered":"Factores determinantes de la respuesta terap\u00e9utica en pacientes afectos de hepattitis cr\u00f3nica por la infecci\u00f3n de l virus de la hepatitis c"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Castellano Higuera Ana Isabel <\/strong><\/h2>\n<p>Realizamos un estudio prospectivo donde se incluyeron 66 pacientes con infecci\u00f3n por el virus de la hepatitis c con biopsia hep\u00e1tica para determinar factores antioxidantes  (como la glutation peroxidasa y superoxido dismutasa as\u00ed como vitaminas a, e, c), factores de peroxidaci\u00f3n lip\u00eddica ( como el malonildialdehido) , niveles de citocinas proinflamatorias (como la il-4, il-6, il-8, tnf-alfa, ifn ganma) as\u00ed como marcadores s\u00e9ricos profibrog\u00e9nicos (como el timp1, adiponectina y tgf- beta) al compararlos con un grupo control.  observando que los pacientes presentaban, respecto al grupo control, niveles m\u00e1s alevados de peroxidaci\u00f3n lip\u00eddica, il-8, tnf-alfa, ifn- ganma y tgf-beta con niveles descendiso de il-6. Lo que sugiere un incremento de la respuesta inmunol\u00f3gica tipo th1 y th3 con un descenso de la th2. (Se observ\u00f3 una relaci\u00f3n directa ntre la peroxidaci\u00f3n lip\u00eddica y la respuesta inflamatoria e inversa con los niveles antioxidantes).  al compara el subgrupo de alcoh\u00f3licos con los no bebedores , los primeros (alcoh\u00f3licos) presentaban una intensificaci\u00f3n de la respuesta th1 y th3 y un mayor compromiso de la repuesta th2 desde el inicio, no existiendo diferencias en estos par\u00e1metros al comparar el otro subrupo de pacientes coinfectados con los no coinfectados. la respuesta al tratamiento fue del 25 % y al intentar determinar los factores predictores de respuesta solo la gpx y el \u00edndice de  knodell resultaron predictores de repuesta. tambi\u00e9n se valor\u00f3 la relaci\u00f3n de los par\u00e1metros anteriormente descritos con funci\u00f3n hepatica y citol\u00edtica y  con la actividad histol\u00f3gica, encontrando una relaci\u00f3n directa entre la alb\u00famina y la actividad de la protrombina con el tnf-alfa, la vitamina a y el \u00edndice de knodell.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores determinantes de la respuesta terap\u00e9utica en pacientes afectos de hepattitis cr\u00f3nica por la infecci\u00f3n de l virus de la hepatitis c<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores determinantes de la respuesta terap\u00e9utica en pacientes afectos de hepattitis cr\u00f3nica por la infecci\u00f3n de l virus de la hepatitis c <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Castellano Higuera Ana Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Gonzalez Reimers Carlos Emilio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Luis Hernandez nieto <\/li>\n<li>alicia Conde martel (vocal)<\/li>\n<li>pedro Abreu gonzalez (vocal)<\/li>\n<li>pedro Pe\u00f1a quintana (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Castellano Higuera Ana Isabel Realizamos un estudio prospectivo donde se incluyeron 66 pacientes con infecci\u00f3n por el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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