{"id":61923,"date":"2018-03-09T22:49:48","date_gmt":"2018-03-09T22:49:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-histopatologico-e-inmunohistoqua%c2%admico-del-higado-y-ganglios-linfaticos-hepaticos-en-cabras-inmunizadas-frente-a-fasciola-hepatica\/"},"modified":"2018-03-09T22:49:48","modified_gmt":"2018-03-09T22:49:48","slug":"estudio-histopatologico-e-inmunohistoqua%c2%admico-del-higado-y-ganglios-linfaticos-hepaticos-en-cabras-inmunizadas-frente-a-fasciola-hepatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia-veterinaria\/estudio-histopatologico-e-inmunohistoqua%c2%admico-del-higado-y-ganglios-linfaticos-hepaticos-en-cabras-inmunizadas-frente-a-fasciola-hepatica\/","title":{"rendered":"Estudio histopatol\u00f3gico e inmunohistoqu\u00edmico del higado y ganglios linf\u00e1ticos hep\u00e1ticos en cabras inmunizadas frente a fasciola hepatica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Zafra Leva <\/strong><\/h2>\n<p>El objetivo del presente estudio ha sido evaluar la eficacia protectora, as\u00ed como las lesiones y respuestas inmune local y sist\u00e9mica inducidas por los ant\u00edgenos glutati\u00f3n-s-transferasa (gst) de f.Hepatica y un p\u00e9ptido sint\u00e9tico (psm14) derivado del ant\u00edgeno sm14 de schistosoma mansoni.     para este estudio se utilizaron 21 cabras de 4 meses de edad de raza florida sevillana, que fueron divididas en tres grupos de 6 animales cada uno: control positivo de infecic\u00f3n (grupo 2); grupo inmunizado con 3 dosis de 200 ug de gst de fasciola hep\u00e1tica utilizando como adyuvante f.C.A y f.I.A. (Grupo 3) y el \u00faltimo grupo inmunizado con 3 dosis de 80 ug del p\u00e9ptido sint\u00e9tico derivado del ant\u00edgeno sm14 compuesto por diez amino\u00e1cidos, cuya secuencia es \u00abn\u00bb-ekn\/ses\/klt\/q\u00bbc\u00bb utilizando como adyuvante 0,66ml de ribi(r) (sigma) y ai(oh)3 (grupo 4). C\u00f3mo control no inmunizadoni infectado se utiliz\u00f3 un grupo de 3 animales.  la inmunizaci\u00f3n se realiz\u00f3 mediante una inoculaci\u00f3n subcut\u00e1nea en la regi\u00f3n del hombro con un intervalo entre ellas de 10 d\u00edas. Los animales de los grupos 2, 3 y 4 fueron infectados oralmente con una dosis de 200 metacercarias de f.Hepatica (mc) procedentes del central veterinay laboratory de weybridge, reino unido. Posteriormente los animales se eutanasiaron utilizando t-61 (invervet, espa\u00f1a).     en la experiencia se llevaron a cabo estudios parasicol\u00f3gicos, anatomopatol\u00f3gicos y morfom\u00e9tricos. El estudio parasitol\u00f3gico revel\u00f3 un descenso en el n\u00famero de par\u00e1sitos obtenidos en el grupo 4 respecto a los grupos 2 y 3, observ\u00e1ndose un 46% menos de par\u00e1sitos.     el estudio anatomopatol\u00f3gico demostr\u00f3 un descenso en las lesiones macro y microsc\u00f3picas observadas en el grupo 4 respecto a los grupos 2 y 3. En los n\u00f3dulos linf\u00e1ticos hep\u00e1ticos no se observ\u00f3 diferencias entre los grupos. el estudio morfom\u00e9trico aplicado a la superficie hep\u00e1tica demostr\u00f3 un descenso en las lesiones observadas en el grupo 4 respecto a las observad<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio histopatol\u00f3gico e inmunohistoqu\u00edmico del higado y ganglios linf\u00e1ticos hep\u00e1ticos en cabras inmunizadas frente a fasciola hepatica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio histopatol\u00f3gico e inmunohistoqu\u00edmico del higado y ganglios linf\u00e1ticos hep\u00e1ticos en cabras inmunizadas frente a fasciola hepatica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Zafra Leva <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Perez Arevalo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Hern\u00e1ndez Rodr\u00edguez <\/li>\n<li>Grace Mulcahy (vocal)<\/li>\n<li> Martinez Moreno Fco. Javier (vocal)<\/li>\n<li> Jaber Mohamad Jos\u00e9 Raduan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Zafra Leva El objetivo del presente estudio ha sido evaluar la eficacia protectora, as\u00ed como las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[973,20868,661,541,495],"tags":[136760,136762,36673,136761,136759,3217],"class_list":["post-61923","post","type-post","status-publish","format-standard","hentry","category-cordoba","category-inmunologia-veterinaria","category-parasitologia-animal","category-patologia-animal","category-patologia-veterinaria","tag-grace-mulcahy","tag-jaber-mohamad-jose-raduan","tag-jose-perez-arevalo","tag-Martinez-moreno-fco-javier","tag-rafael-zafra-leva","tag-santiago-hernandez-rodriguez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/61923","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=61923"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/61923\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=61923"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=61923"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=61923"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}