{"id":61930,"date":"2018-03-09T22:49:48","date_gmt":"2018-03-09T22:49:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-experiimental-de-las-va%c2%adas-del-dolor-de-la-region-de-las-vibrisas-en-el-cobaya-tricolor-cavia-porcellus\/"},"modified":"2018-03-09T22:49:48","modified_gmt":"2018-03-09T22:49:48","slug":"estudio-experiimental-de-las-va%c2%adas-del-dolor-de-la-region-de-las-vibrisas-en-el-cobaya-tricolor-cavia-porcellus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-experiimental-de-las-va%c2%adas-del-dolor-de-la-region-de-las-vibrisas-en-el-cobaya-tricolor-cavia-porcellus\/","title":{"rendered":"Estudio experiimental de las v\u00edas del dolor de la regi\u00f3n de las vibrisas en el cobaya tricolor (cavia porcellus)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Silvia Nov\u00edo Mall\u00f3n <\/strong><\/h2>\n<p>Se ha investigado en el cobaya tricolor (cavia porcellus) la expresi\u00f3n del protooncog\u00e9n c-fos en el complejo nuclear sensitivo del trig\u00e9mino y en aquellas estructuras del bulbo raqu\u00eddeo relacionadas con las v\u00edas centrales del dolor cut\u00e1neo facial, como son el complejo parabraquial pontino, la formaci\u00f3n reticular adyacente al complejo nuclear sensitivo del trig\u00e9mino y los n\u00facleos paratrigeminales. Para ello, se inyectaron tres irritantes qu\u00edmicos en la regi\u00f3n central subcut\u00e1nea de las vibrisas: formalina, capsaicina y aceite de mostaza. Las dos primeras sustancias son ampliamente empleadas en test del dolor experimental, mientras que el aceite de mostaza es un irritante al que se recurre para inducir hiperalgesia, alodinia e inflamaci\u00f3n local. Adem\u00e1s, tambi\u00e9n se analiz\u00f3 la posible modulaci\u00f3n ejercida por el sistema gabab sobre esta expresi\u00f3n de c-fos, mediante la inyecci\u00f3n sist\u00e9mica de un agonista (baclofeno) y de un antagonista (faclofeno). Para un mejor an\u00e1lisis de la v\u00eda dolorosa de las vibrisas, se investig\u00f3 la expresi\u00f3n central de dos neurop\u00e9ptidos presentes en fibras nociceptivas (cgrp y sustancia p), y la representaci\u00f3n central de las aferentes primarias de las vibrisas mediante tres neurotrazadores: toxina del c\u00f3lera b conjugada con la peroxidasa de r\u00e1bano (ctb-hrp), aglutinina de trigo conjugada con hrp (wga-hrp) e isolectina b4 de bandeiraea simplicifolia conjugada con hrp (ib4-hrp). la aplicaci\u00f3n de las tres sustancias irritantes en la regi\u00f3n de las vibrisas produjo expresi\u00f3n de c-fos en el n\u00facleo caudal del trig\u00e9mino y asta dorsal del primer segmento cervical (c1), en los n\u00facleos paratrigeminales dorsal y ventral, y en las subdivisiones rostrales del complejo nuclear sensitivo del trig\u00e9mino: n\u00facleos interpolar, oral y principal (en este caso s\u00f3lo con aceite de mostaza). Adem\u00e1s, estas sustancias produjeron expresi\u00f3n de c-fos bilateralmente en el complejo parabraquial pontino y en la formaci\u00f3n reticular adyacente al<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio experiimental de las v\u00edas del dolor de la regi\u00f3n de las vibrisas en el cobaya tricolor (cavia porcellus)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio experiimental de las v\u00edas del dolor de la regi\u00f3n de las vibrisas en el cobaya tricolor (cavia porcellus) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Silvia Nov\u00edo Mall\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Alberto G\u00f3mez Segade<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Jorge Barreiro Francisco Javier <\/li>\n<li>Ram\u00f3n Anadon \u00e1lvarez (vocal)<\/li>\n<li>Andr\u00e9s Beiras Iglesias (vocal)<\/li>\n<li>Francisco Javier Cudeiro Mazaira (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Silvia Nov\u00edo Mall\u00f3n Se ha investigado en el cobaya tricolor (cavia porcellus) la expresi\u00f3n del protooncog\u00e9n c-fos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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