{"id":61937,"date":"2018-03-09T22:49:48","date_gmt":"2018-03-09T22:49:48","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/importancia-de-los-genes-fur-y-thya-en-la-patogenia-de-haemophilus-parasuis\/"},"modified":"2018-03-09T22:49:48","modified_gmt":"2018-03-09T22:49:48","slug":"importancia-de-los-genes-fur-y-thya-en-la-patogenia-de-haemophilus-parasuis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/importancia-de-los-genes-fur-y-thya-en-la-patogenia-de-haemophilus-parasuis\/","title":{"rendered":"Importancia de los genes fur y thya en la patogenia de haemophilus parasuis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Anna Bigas Terricabras <\/strong><\/h2>\n<p>Haemophilus parasuis es un miembro de la familia pasteurellaceae y un importante pat\u00f3geno del tracto respiratorio porcino, causante de la enermedad de gl\u00ed\u00a4sser. En la actualidad, esta enfermedad es una de las que tiene mayor incidencia en el sector porcino con una elevada repercusi\u00f3n econ\u00f3mica. Por este motivo, es necesario estudiar la biolog\u00eda molecular de este pat\u00f3geno para poder desarrollar vacunas m\u00e1s eficientes que las existentes hasta el presente. Para abordar este estudio es imprescindible disponer de alg\u00fan proceso de transferencia gen\u00e9tica eficaz en h. Parasuis. No obstante, dado el desconocimiento que se ten\u00eda de dicho pat\u00f3geno, no se conoc\u00eda ning\u00fan  mecanismo natural o de laboratorio que permitiera introducir dna en h. Parasuis. Por ello, el primer objetivo del presente trabajo ha sido desarrollar un m\u00e9todo de transferencia gen\u00e9tica en h. Parasuis que permita estudiar posteriormente los genes implicados en su virulencia y en la colonizaci\u00f3n del hospedador. en la presente tesis se ha demostrado por vez primera que h. Parasuis es capaz de transformar de forma natural si el dna ex\u00f3geno contiene la secuencia accgaactc, la cual es muy similar al motivo accgcactt descrito en h. Influenzae como uptake signal sequence. Adem\u00e1s, se ha optimizado este proceso, determinando las concentraciones m\u00e1s adecuadas de c\u00e9lulas bacterianas, ampc y dna transformante, as\u00ed como el tiempo de incubaci\u00f3n. un segundo objetivo de estre trabajo ha sido averiguar el papel de la timidilato sintasa, enzima clave en la s\u00edntesis de desoxitimidina monofosfato (dtmp), en la virulencia de h. Parasuis. Para ello, se ha construido un mutante knockout en el gen thya de h. Parasuis y se ha determinado la capacidad de colonizaci\u00f3n y la inmunogenicidad de la cepa salvaje y de dicho mutante thya en un modelo animal de cobayas. Los resultados han mostrado que la cepa defectiva en la enzima timidilato sintasa tienen una menor capaciad de colonizaci\u00f3n, a pesar de que es capaz de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Importancia de los genes fur y thya en la patogenia de haemophilus parasuis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Importancia de los genes fur y thya en la patogenia de haemophilus parasuis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Anna Bigas Terricabras <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Montserrat Llagostera Casas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Vi\u00f1as Ciordia <\/li>\n<li>Elisenda Mir\u00f3 Cardona (vocal)<\/li>\n<li>Fernando Alcaide  Fernandez De Vega (vocal)<\/li>\n<li>Montserrat Bosch Gallego (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Anna Bigas Terricabras Haemophilus parasuis es un miembro de la familia pasteurellaceae y un importante pat\u00f3geno del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,2118,2391],"tags":[86586,136793,86347,1241,69372,61708],"class_list":["post-61937","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-genetica-veterinaria","category-microbiologia-veterinaria","tag-anna-bigas-terricabras","tag-elisenda-miro-cardona","tag-fernando-alcaide-fernandez-de-vega","tag-miguel-vinas-ciordia","tag-montserrat-bosch-gallego","tag-montserrat-llagostera-casas"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/61937","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=61937"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/61937\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=61937"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=61937"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=61937"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}