{"id":61959,"date":"2018-03-09T22:49:51","date_gmt":"2018-03-09T22:49:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-adicion-de-compuestos-organometalicos-a-iminas-derivadas-de-d-gliceraldeha%c2%addo-sa%c2%adntesis-de-productos-de-interes-biologico\/"},"modified":"2018-03-09T22:49:51","modified_gmt":"2018-03-09T22:49:51","slug":"estudio-de-la-adicion-de-compuestos-organometalicos-a-iminas-derivadas-de-d-gliceraldeha%c2%addo-sa%c2%adntesis-de-productos-de-interes-biologico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/estereoquimica-y-analisis-conformacional\/estudio-de-la-adicion-de-compuestos-organometalicos-a-iminas-derivadas-de-d-gliceraldeha%c2%addo-sa%c2%adntesis-de-productos-de-interes-biologico\/","title":{"rendered":"Estudio de la adici\u00f3n de compuestos organomet\u00e1licos a iminas derivadas de d-gliceraldeh\u00eddo.s\u00edntesis de productos de inter\u00e9s biol\u00f3gico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  D\u00edez Gracia Roberto Jes\u00fas <\/strong><\/h2>\n<p>El grupo amino es una de las estructuras fundamentales dentro de la qu\u00edmica org\u00e1nica. En particular, las aminas que poseen uncentro quiral en posici\u00f3n alfa y\/o beta desempe\u00f1an un papel muy importante dentro de la industria farmac\u00e9utica, pudiendo serutilizadas como bases, auxiliares quirales, ligand\u00f3s en s\u00edntesis asim\u00e9trica o intermedios en la s\u00edntesis de compuestos con actividadlas iminas derivadas de d-gliceraldeh\u00edd\u00f3 son muy \u00fatiles para efectuar la s\u00edntesis diastereoselectiva de diferentes aminas mediante laadici\u00f3n de compuestos organomet\u00e1licos. El curso estereoqu\u00edmico en este proceso puede controlarse en funci\u00f3n del reactivoorganomet\u00e1lico utilizado, el grupo protector del aldeh\u00eddo de partida o por la presencia de \u00e1cidos de lewis. En algunos casos elproceso de doble estereodiferenciaci\u00f3n, que conlleva la adici\u00f3n de reactives organomet\u00e1licos a iminas derivadas de (r) \u00f3 (s)-1?Feniletilamina,proporcionalas aminas deseadas de forma totalmente. Diastereoselectiva.Adem\u00e1s, las aminas obtenidas en estos procesos son intermedios sint\u00e9ticos muy \u00fatiles en la s\u00edntesis de compuestos nitrogenados conactividad biol\u00f3gica. As\u00ed, la oxidaci\u00f3n del grupo 1,2-etanodiol pemite la obtenci\u00f3n de alfa-amino\u00e1cidos. La manipulaci\u00f3n del dobleenlace de las alilaminas permite la obtenci\u00f3n de derivados de 3-amino-1,2,4-butanotriol. Finalmente la n-alilaci\u00f3n o n-acilaci\u00f3n delas alilaminas y homoalilaminas y posterior reacci\u00f3n de met\u00e1tesis con cierre de anillo permite la obtenci\u00f3n de pirrolidinas ypiperidinas, compuestos que a su vez pueden transformarse en pirrolidinas polihidroxiladas y precursores de alcaloides<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la adici\u00f3n de compuestos organomet\u00e1licos a iminas derivadas de d-gliceraldeh\u00eddo.s\u00edntesis de productos de inter\u00e9s biol\u00f3gico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la adici\u00f3n de compuestos organomet\u00e1licos a iminas derivadas de d-gliceraldeh\u00eddo.s\u00edntesis de productos de inter\u00e9s biol\u00f3gico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  D\u00edez Gracia Roberto Jes\u00fas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda  Dolores Diaz De Villegas Solans<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Mayoral murillo <\/li>\n<li>ricardo Alonso alonso (vocal)<\/li>\n<li>sergio Castillon miranda (vocal)<\/li>\n<li>eva Villarroya apricio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de D\u00edez Gracia Roberto Jes\u00fas El grupo amino es una de las estructuras fundamentales dentro de la qu\u00edmica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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