{"id":61984,"date":"2018-03-09T22:49:51","date_gmt":"2018-03-09T22:49:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/control-de-la-diseminacion-celular-mediante-el-dano-al-dna-implicaciones-en-cancer-y-celulas-stem-del-cancer\/"},"modified":"2018-03-09T22:49:51","modified_gmt":"2018-03-09T22:49:51","slug":"control-de-la-diseminacion-celular-mediante-el-dano-al-dna-implicaciones-en-cancer-y-celulas-stem-del-cancer","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/salamanca\/control-de-la-diseminacion-celular-mediante-el-dano-al-dna-implicaciones-en-cancer-y-celulas-stem-del-cancer\/","title":{"rendered":"Control de la diseminaci\u00f3n celular mediante el da\u00f1o al dna: implicaciones en c\u00e1ncer y c\u00e9lulas  stem  del c\u00e1ncer"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Camino Bermejo Rodr\u00edguez <\/strong><\/h2>\n<p>P53 es la principal prote\u00edna implicada en la respuesta que se produce tras da\u00f1o en el dna, que induce una parada de ciclo celular para conceder tiempo a las c\u00e9lulas para la reparaci\u00f3n del dna da\u00f1ado y, en caso de que la reparaci\u00f3n no sea posible, provoca la eliminaci\u00f3n de las c\u00e9lulas da\u00f1adas. En ese momento en que las c\u00e9lulas est\u00e1n paradas decidiendo si deben vivir o morir, estar\u00edan en condiciones de migrar. Nosotros hemos observado que el da\u00f1o en el dna controla la diseminaci\u00f3n celular de una forma dependiente de p53. slug, un miembro de la familia snail de factores de transcripci\u00f3n, ha sido implicado en los movimientos celulares que se producen durante el desarrollo embrionario y durante la progresi\u00f3n tumoral. El papel de slug en la supervivencia celular tambi\u00e9n podr\u00eda ser importante para la progresi\u00f3n del c\u00e1ncer. Por ello, slug deber\u00eda ser regulado tras da\u00f1o en el dna con el fin de evitar la supervivencia y migraci\u00f3n de c\u00e9lulas da\u00f1adas. Nosotros hemos observado que slug se regula en respuesta al da\u00f1o en el dna de una forma dependiente de p53. De acuerdo con esta observaci\u00f3n, slug ha mostrado jugar un papel oncog\u00e9nico en la tumorog\u00e9nesis de p53, puesto que la expresi\u00f3n no regulable de slug en ratones p53-\/- hace que los tumores aparezcan en edades mucho m\u00e1s tempranas que en los ratones p53-\/-, y adem\u00e1s los tumores son de mayor tama\u00f1o y muy agresivos e invasivos. por otro lado, la supresi\u00f3n de la expresi\u00f3n de slug en ratones p53-\/- ha mostrado que slug tambi\u00e9n desempe\u00f1a un papel como supresor de tumores, puesto que la ausencia de expresi\u00f3n de slug en ratones p53-\/- provoca la aparici\u00f3n de un espectro de tumores diferente y m\u00e1s amplio. por lo tanto, la principal conclusi\u00f3n de nuestro estudio es que el da\u00f1o en el dna controla la diseminaci\u00f3n celular mediante el eje molecular p53-slug.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Control de la diseminaci\u00f3n celular mediante el da\u00f1o al dna: implicaciones en c\u00e1ncer y c\u00e9lulas  stem  del c\u00e1ncer<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Control de la diseminaci\u00f3n celular mediante el da\u00f1o al dna: implicaciones en c\u00e1ncer y c\u00e9lulas  stem  del c\u00e1ncer <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Camino Bermejo Rodr\u00edguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isidro Javier S\u00e1nchez Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Jes\u00fas Cruz hern\u00e1ndez <\/li>\n<li>Antonio Garcia de herreros madue\u00f1o (vocal)<\/li>\n<li>amparo Cano garcia (vocal)<\/li>\n<li>M\u00aa \u00e1ngela Nieto toledano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Camino Bermejo Rodr\u00edguez P53 es la principal prote\u00edna implicada en la respuesta que se produce tras da\u00f1o [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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