{"id":62025,"date":"2018-03-09T22:49:55","date_gmt":"2018-03-09T22:49:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-acidosis-metabolica-sobre-el-hiperparatiroidismo-secundario-y-la-calcificacia%c2%b2n-extraesqueletica\/"},"modified":"2018-03-09T22:49:55","modified_gmt":"2018-03-09T22:49:55","slug":"efecto-de-la-acidosis-metabolica-sobre-el-hiperparatiroidismo-secundario-y-la-calcificacia%c2%b2n-extraesqueletica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/accion-de-los-farmacos\/efecto-de-la-acidosis-metabolica-sobre-el-hiperparatiroidismo-secundario-y-la-calcificacia%c2%b2n-extraesqueletica\/","title":{"rendered":"Efecto de la acidosis metab\u00f3lica sobre el hiperparatiroidismo secundario y la calcificaci\u00f3n extraesquel\u00e9tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Javier Mendoza Garcia <\/strong><\/h2>\n<p>Los enfermos renales cr\u00f3nicos desarrollan hiperparatiroidismo renal secundario (hpt2). En estos pacientes la principal causa de muerte son las enfermedades cardiovasculares, que generalmente se asocian a la existencia de calcificaci\u00f3n vascular y de otros tejidos blandos. La calcificaci\u00f3n extra\u00f3sea puede verse potenciada por algunos de los tratamientos que se usan para controlar el hpt2, como los an\u00e1logos de la vitamina d. La insuficiencia renal cr\u00f3nica, tambi\u00e9n suele cursar con acidosis metab\u00f3lica (am). En este trabajo se ha estudiado el efecto de la am sobre las gl\u00e1ndulas paratiroides y su influencia en el desarrollo de la calcificaci\u00f3n extraesquel\u00e9tica en modelos de ratas ur\u00e9micas tratadas con calcitriol y\/o con calcimim\u00e9ticos. Los resultados obtenidos demuestran que la am aguda disminuye la expresi\u00f3n del receptor sensor de calcio (arnmcasr) en c\u00e9lulas paratiroides de rata tanto in vivo como in vitro. Este descenso del arnmcasr paratiroideo est\u00e1 modulado por los cambios en la calcemia: la hipocalcemia lo potencia y la hipercalcemia lo aten\u00faa. Adem\u00e1s, la administraci\u00f3n del calcimim\u00e9tico nps r-568 a ratas acid\u00f3ticas previene y revierte el descenso de arnmcasr provocado por la am. Por otra parte, se ha constatado que la administaci\u00f3n de calcitriol a ratas ur\u00e9micas con una dieta elevada en f\u00f3sforo, en dosis suficientes para controlar el hpt2, provoca calcificaci\u00f3n extraesquel\u00e9tica. Sin embargo, el tratamiento con los calcimim\u00e9ticos hps r-568 y amg 641 consigue controlar el hpt2 y no produce calcificaci\u00f3n extra\u00f3sea. Adem\u00e1s, cuando los calcimim\u00e9ticos se combinan con calcitriol consiguen reducir la calcificaci\u00f3n provocada por este \u00faltimo. Finalmente, se ha constatado que la acidosis metab\u00f3lica cr\u00f3nica previene la calcificaci\u00f3n extraesquel\u00e9tica en ratas ur\u00e9micas tratadas con calcitriol, a pesar de que estos animales tienen incrmentado el producto ca x p sangu\u00edneo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la acidosis metab\u00f3lica sobre el hiperparatiroidismo secundario y la calcificaci\u00f3n extraesquel\u00e9tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la acidosis metab\u00f3lica sobre el hiperparatiroidismo secundario y la calcificaci\u00f3n extraesquel\u00e9tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Javier Mendoza Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Escolastico Aguilera Tejero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Rafael Mayer Valor <\/li>\n<li>Jos\u00e9 Carlos Gomez Villamandos (vocal)<\/li>\n<li>Jordi Bover SanJuan (vocal)<\/li>\n<li>Jos\u00e9 Carlos Estepa Nieto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Javier Mendoza Garcia Los enfermos renales cr\u00f3nicos desarrollan hiperparatiroidismo renal secundario (hpt2). En estos pacientes la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[44,973,179,1601],"tags":[52263,136995,136996,85768,40655,3236],"class_list":["post-62025","post","type-post","status-publish","format-standard","hentry","category-accion-de-los-farmacos","category-cordoba","category-nefrologia","category-patologia-cardiovascular","tag-escolastico-aguilera-tejero","tag-francisco-javier-mendoza-garcia","tag-jordi-bover-sanjuan","tag-jose-carlos-estepa-nieto","tag-jose-carlos-gomez-villamandos","tag-rafael-mayer-valor"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/62025","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=62025"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/62025\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=62025"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=62025"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=62025"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}