{"id":62052,"date":"2018-03-09T22:49:55","date_gmt":"2018-03-09T22:49:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/metabolismo-del-hierro-inflamacion-y-anemia-en-pacientes-criticos\/"},"modified":"2018-03-09T22:49:55","modified_gmt":"2018-03-09T22:49:55","slug":"metabolismo-del-hierro-inflamacion-y-anemia-en-pacientes-criticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica-inmunologica\/metabolismo-del-hierro-inflamacion-y-anemia-en-pacientes-criticos\/","title":{"rendered":"Metabolismo del hierro, inflamacion y anemia en pacientes criticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuela Mar\u00eda Morales Garces <\/strong><\/h2>\n<p>Introducci\u00f3n. La deficiencia funciona de hierro (dfh) causada por la inflamaci\u00f3n no es solo una de las causas de anemia en el paciente cr\u00edtico, sino que tambi\u00e9n induce una respuesta inapropiada del sistema inmunitario, lo que origina una mayor duraci\u00f3n de los episodios de respuesta inflamatoria sist\u00e9mica y un peor pron\u00f3stico.  objetivo. Este estudio transversal prospectivo se inici\u00f3 para evaluar la preValencia de dfh en pacientes cr\u00edticos durante su estancia en la uci, y determinar la poblaci\u00f3n de pacientes que podr\u00edan beneficiarse de la administraci\u00f3n de hierro intravenoso.  m\u00e9todos. Se realizaron recuentos hematol\u00f3gicos completos, incluyendo reticulocitos (retic), y determinaci\u00f3n de los niveles s\u00e9ricos de hierro (si), transferrina (trf) y porcentaje de saturaci\u00f3n (sattrf), receptor soluble de tfr (stfr), ferritina (frt) y prote\u00edna c-reactiva (crp) en muestras de sangre venosa de 131 pacientes ingresados en uci durante al menos 24 horas (estancia en uci, min: 1 d\u00eda; max: 38 d\u00edas).  resultados. Se detect\u00f3 la presencia de anemia (hb<12 g\/dl) en el 76% de los pacientes (hb<10 g\/dl en el 33%), de hiposideremia (si<45 mg\/dl) en el 69%; una sattrf<20% en el 53%; una frt<100 ng\/ml en el 23%, un nivel de stfr>2.3 mg\/dl en el 13%; y de crp>0.5 mg\/dl en el 88%. Se obtuvieron correlaciones significativas (r de pearson; *p<0.05, **p<0.01) entre los niveles de crp y los de wbc**, hb*, trf**, sattrf*, y frt**. Hubo tambi\u00e9n una fuerte correlaci\u00f3n entre trf y frt (-0.650**), pero no entre frt y sattrf o si. La estancia en uci se correlacion\u00f3 con hb*, crp**, trf*, sattrf*, y frt**.  conclusiones. Una gran parte de los pacientes cr\u00edticos ingresados en la uci presentan el dfh t\u00edpico de la anemia relacionada con los episodios agudos (area). Este dfh se correlaciona con el estado inflamatorio y la duraci\u00f3n de la estancia en uci: sin embargo, el 19% de los pacientes en uci con area presentan adem\u00e1s un d\u00e9ficit real de hierro (sattrf<20; frt<100, and stfr>1.9). Dado que el tratamiento con hierro oral parece ser infectivo, estos pacientes podr\u00edan beneficiarse de la terapia con hierro intravenoso para la correcci\u00f3n de su deficiencia real o funcional de hierro, lo que a su vez podr\u00eda contribuir a una disminuci\u00f3n de su estado inflamatorio.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Metabolismo del hierro, inflamacion y anemia en pacientes criticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Metabolismo del hierro, inflamacion y anemia en pacientes criticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuela Mar\u00eda Morales Garces <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Mu\u00f1oz Gomez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  gemma Ramirez ramirez <\/li>\n<li>Jorge Cuenca espierrez (vocal)<\/li>\n<li>enrique Naveira abeigon (vocal)<\/li>\n<li>Jos\u00e9 Antonio Garcia ere (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuela Mar\u00eda Morales Garces Introducci\u00f3n. La deficiencia funciona de hierro (dfh) causada por la inflamaci\u00f3n no es [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2148,2612,7834],"tags":[61204,41695,137055,42926,137053,137054],"class_list":["post-62052","post","type-post","status-publish","format-standard","hentry","category-bioquimica-inmunologica","category-inmunoquimica","category-malaga","tag-enrique-naveira-abeigon","tag-jorge-cuenca-espierrez","tag-jose-antonio-garcia-ere","tag-manuel-munoz-gomez","tag-manuela-maria-morales-garces","tag-maria-gemma-ramirez-ramirez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/62052","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=62052"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/62052\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=62052"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=62052"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=62052"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}