{"id":62079,"date":"2018-03-09T22:49:59","date_gmt":"2018-03-09T22:49:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-bioinformatico-del-promotor-proximal-para-predecir-mecanismos-de-corregulacion-del-a-expresion-genica\/"},"modified":"2018-03-09T22:49:59","modified_gmt":"2018-03-09T22:49:59","slug":"analisis-bioinformatico-del-promotor-proximal-para-predecir-mecanismos-de-corregulacion-del-a-expresion-genica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica\/analisis-bioinformatico-del-promotor-proximal-para-predecir-mecanismos-de-corregulacion-del-a-expresion-genica\/","title":{"rendered":"An\u00e1lisis bioinform\u00e1tico del promotor proximal para predecir mecanismos de corregulaci\u00f3n del a expresi\u00f3n g\u00e9nica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elisabet Guruceaga Martinez <\/strong><\/h2>\n<p>An\u00e1lisis bioinformatico del promotor proximal para predecir mecanismos de corregulacion de la expresi\u00f3n genica #resumen: los experimentos de expresi\u00f3n g\u00e9nica a gran escala mediante microarrays de dna permiten estudiar los sistemas biol\u00f3gicos con gran eficacia. El an\u00e1lisis de los datos de expresi\u00f3n a nivel gen\u00f3mico puede esclarecer los mecanismos asociados tanto a respuestas adaptativas celulares como a la progresi\u00f3n de enfermedades. Sin embargo, la interpretaci\u00f3n de las descripciones moleculares generadas continua siendo un reto para 1os investigadores. El desarrollo de nuevas herramientas para identificar los mecanismos de regulaci\u00f3n responsables de la coexpresi\u00f3n de un conjunto de genes puede incrementar la capacidad de extraer informaci\u00f3n funcional relevante a partir de los datos de expresi\u00f3n g\u00e9nica. Esta tesis describe la aplicaci\u00f3n web factory que incluye una base de datos denominada promoterdb, m\u00e9todos estad\u00edsticos para analizar el enriquecimiento de motivos de uni\u00f3n a factores de transcripci\u00f3n en el promotor de genes coexpresados y herramientas bioinform\u00e1ticas para la interpretaci\u00f3n de los resultados. Promoterdb almacena las secuencias del promotor proximal de los genomas de humano, rat\u00f3n y rata y la posici\u00f3n de los motivos detectados en dichas secuencias.La metodolog\u00eda desarrollada ha sido evaluada con datos p\u00fablicos ycon un experimento de microarrays en el que se estudia el efecto biol\u00f3gico inducido en c\u00e9lulas hepg2 por el tratamiento con distintos subtipos de interfer\u00f3n-alpha.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis bioinform\u00e1tico del promotor proximal para predecir mecanismos de corregulaci\u00f3n del a expresi\u00f3n g\u00e9nica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis bioinform\u00e1tico del promotor proximal para predecir mecanismos de corregulaci\u00f3n del a expresi\u00f3n g\u00e9nica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elisabet Guruceaga Martinez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Fernando Jose Corrales Izquierdo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas m. Prieto valtue\u00f1a <\/li>\n<li>Javierde las Rivas sanz (vocal)<\/li>\n<li>alexandre Sanchez pla (vocal)<\/li>\n<li>Alberto Pascual montano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elisabet Guruceaga Martinez An\u00e1lisis bioinformatico del promotor proximal para predecir mecanismos de corregulacion de la expresi\u00f3n genica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[36483,962,17749],"tags":[61440,137109,137108,42714,3402,15059],"class_list":["post-62079","post","type-post","status-publish","format-standard","hentry","category-biologia-molecular","category-genetica","category-navarra","tag-alberto-pascual-montano","tag-alexandre-sanchez-pla","tag-elisabet-guruceaga-Martinez","tag-fernando-jose-corrales-izquierdo","tag-javierde-las-rivas-sanz","tag-jesus-m-prieto-valtuena"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/62079","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=62079"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/62079\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=62079"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=62079"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=62079"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}