{"id":6210,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/radioproteccion-conferida-por-polisacaridos-ionicos-en-raton-relacion-con-su-capacidad-para-estimular-el-sistema-hematopoyetico\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"radioproteccion-conferida-por-polisacaridos-ionicos-en-raton-relacion-con-su-capacidad-para-estimular-el-sistema-hematopoyetico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/radioproteccion-conferida-por-polisacaridos-ionicos-en-raton-relacion-con-su-capacidad-para-estimular-el-sistema-hematopoyetico\/","title":{"rendered":"Radioproteccion conferida por polisacaridos ionicos en raton. relacion con su capacidad para estimular el sistema hematopoyetico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Guillermo Guenechea Amurrio <\/strong><\/h2>\n<p>El da\u00f1o inducido sobre el sistema hematopoyetico es la principal causa de muerte tras la exposicion a dosis moderadas de radiacion, siendo en este contexto indiscutible la importancia de compuestos con capacidad para proteger y\/o estimular el sistema hematopoyetico.En esta memoria, nos hemos centrado en el analisis de la capacidad de tres polisacaridos polianionicos, am218, am250 y am251, para estimular la hematopoyesis murina tanto en condiciones normales como en casos de exposicion a radiacion y confirmar asi su potencial aplicacion como terapia de apoyo en tratamientos mielosupresores. Los resultados demuestran que el tratamiento con los polisacaridos estimula la hematopoyesis esplenica y medular, si bien en la medula osea dicha estimulacion solo se pone de manifiesto in vitro. Ademas, los tres polisacaridos muestran una elevada capacidad radioprotectora cuando son administrados antes de una irradiacion potencialmente letal. Profundizando en los mecanismos de accion de los polisacaridos, se ha puesto de manifiesto que su capacidad radioprotectora esta asociada con su actividad estimuladora sobre el sistema hematopoyetico, acortando el periodo de pancitopenia post-irradiacion, asi como con su capacidad para disminuir la radiosensibilidad de precursores hematopoyeticos, aminorando el da\u00f1o radioinducido. Por ultimo, se demostro que los polisacaridos promueven la sintesis de factores hematopoyeticos, a traves de los cuales ejercerian su accion sobre el sistema hematopoyetico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Radioproteccion conferida por polisacaridos ionicos en raton. relacion con su capacidad para estimular el sistema hematopoyetico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Radioproteccion conferida por polisacaridos ionicos en raton. relacion con su capacidad para estimular el sistema hematopoyetico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Guillermo Guenechea Amurrio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Almudena Real Gallego<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Agustin Gregorio Zapata Gonzalez <\/li>\n<li>Juan  Antonio Bueren Roncero (vocal)<\/li>\n<li>Mar\u00eda  Monica De La Fuente Del Rey (vocal)<\/li>\n<li>Julio Coll Morales (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Guillermo Guenechea Amurrio El da\u00f1o inducido sobre el sistema hematopoyetico es la principal causa de muerte tras [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,35,9399,2992],"tags":[6521,23526,23525,17439,3033,4610],"class_list":["post-6210","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-ciencias-de-la-vida","category-cultivo-celular","category-radiobiologia","tag-agustin-gregorio-zapata-gonzalez","tag-almudena-real-gallego","tag-guillermo-guenechea-amurrio","tag-juan-antonio-bueren-roncero","tag-julio-coll-morales","tag-maria-monica-de-la-fuente-del-rey"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/6210","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=6210"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/6210\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=6210"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=6210"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=6210"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}