{"id":62187,"date":"2018-03-09T22:50:06","date_gmt":"2018-03-09T22:50:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-variables-inmunologicas-y-bacteriologicas-en-relacion-con-la-inmunizacion-frente-a-paratuberculosis-en-los-rumiantes\/"},"modified":"2018-03-09T22:50:06","modified_gmt":"2018-03-09T22:50:06","slug":"estudio-de-variables-inmunologicas-y-bacteriologicas-en-relacion-con-la-inmunizacion-frente-a-paratuberculosis-en-los-rumiantes","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/patologia-veterinaria\/estudio-de-variables-inmunologicas-y-bacteriologicas-en-relacion-con-la-inmunizacion-frente-a-paratuberculosis-en-los-rumiantes\/","title":{"rendered":"Estudio de variables inmunol\u00f3gicas y bacteriol\u00f3gicas en relaci\u00f3n con la inmunizaci\u00f3n frente a paratuberculosis en los rumiantes."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  V. Geijo Vazquez <\/strong><\/h2>\n<p>La paratuberculosis es una enteritis granulomatosa de curso cr\u00f3nico y etiolog\u00eda infecciosa producida por mycobacterium avium subsp. Paratuberculosis (map) que afecta a numerosas especies de rumiantes tanto dom\u00e9sticos como silvestres, as\u00ed como a diferentes especies de monog\u00e1stricos, y cuya vinculaci\u00f3n con la etiolog\u00eda de la enfermedad de crohn humana, aunque no demostrada definitivamente, adquiere cada vez mayor peso. Por tanto, el inter\u00e9s en el estudio de la paratuberculosis no s\u00f3lo se justifica por las grandes p\u00e9rdidas econ\u00f3micas que provoca anualmente en el sector ganadero, sino que podr\u00eda resultar de enorme utilidad como modelo para el estudio de la enfermedad inflamatoria intestinal humana, sin olvidar el impacto social que alcanzar\u00eda si se llegase a demostrar su papel como zoonosis, pasando a convertirse en un grave problema de salud p\u00fablica. Sin embargo, desde las primeras descripciones de la enfermedad realizadas a finales del siglo xix por johne y frothingham, los avances en la comprensi\u00f3n de sus mecanismos inmunopatog\u00e9nicos han sido muy limitados. al inicio de este estudio se plante\u00f3 la necesidad de profundizar en el conocimiento de la patogenia de la paratuberculosis tomando como modelo las tres especies de rumiantes dom\u00e9sticos de principal importancia ganadera. Con el fin de abarcar las posibles variables que pudiesen estar afectando a dicha patogenia, se dise\u00f1\u00f3 un estudio de campo longitudinal con muestreos a los 0, 6, 12 y 18 meses post-vacunaci\u00f3n, en el que se controlaron las variables independientes estado cl\u00ednico de la paratuberculosis y desaf\u00edo antig\u00e9nico mediante vacunaci\u00f3n a tres edades diferentes (menores de 15 d\u00edas, 3 a 6 meses y mayores de 18 meses), con el fin de determinar los efectos de la vacuna sobre las variables carga micobacteriana y respuestas inmunes celular y humoral.  finalmente, se elabor\u00f3 un modelo de patogenia de la paratuberculosis que integra los factores gen\u00e9ticos, mec\u00e1nicos, inmunes y bacteriano<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de variables inmunol\u00f3gicas y bacteriol\u00f3gicas en relaci\u00f3n con la inmunizaci\u00f3n frente a paratuberculosis en los rumiantes.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de variables inmunol\u00f3gicas y bacteriol\u00f3gicas en relaci\u00f3n con la inmunizaci\u00f3n frente a paratuberculosis en los rumiantes. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  V. Geijo Vazquez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Juste Jord\u00e1n Ram\u00f3n A.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  jose Badiola diez <\/li>\n<li>Marta Barral lahidalga (vocal)<\/li>\n<li>douwe Bakker (vocal)<\/li>\n<li>Mar\u00eda no Domingo \u00e1lvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda V. Geijo Vazquez La paratuberculosis es una enteritis granulomatosa de curso cr\u00f3nico y etiolog\u00eda infecciosa producida [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[20868,4430,2391,495],"tags":[137337,4545,69509,7314,137336,67401],"class_list":["post-62187","post","type-post","status-publish","format-standard","hentry","category-inmunologia-veterinaria","category-leon","category-microbiologia-veterinaria","category-patologia-veterinaria","tag-douwe-bakker","tag-juan-jose-badiola-diez","tag-juste-jordan-ramon-a","tag-maria-no-domingo-alvarez","tag-maria-v-geijo-vazquez","tag-marta-barral-lahidalga"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/62187","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=62187"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/62187\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=62187"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=62187"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=62187"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}