{"id":62195,"date":"2018-03-09T22:50:06","date_gmt":"2018-03-09T22:50:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/colloidal-and-molecular-assemblies-for-bioengineering-applications\/"},"modified":"2018-03-09T22:50:06","modified_gmt":"2018-03-09T22:50:06","slug":"colloidal-and-molecular-assemblies-for-bioengineering-applications","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/analisis-electroquimico\/colloidal-and-molecular-assemblies-for-bioengineering-applications\/","title":{"rendered":"Colloidal and molecular assemblies for bioengineering applications"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Paula Pescador \u00e1lvarez <\/strong><\/h2>\n<p>En el presente trabajo se emplea la t\u00e9cnica de autoensamblaje capa por capa (layer-by-layer, lbl) para la creaci\u00f3n de recubrimientos multicapa de enzimas y polielectrolitos sobre la superficie de micropat\u00edculas de s\u00edlice. Dos enzimas diferentes, glucosa oxidasa (gox)  y peroxidasa (hrp) son coinmovilizadas junto con capas precursoras e intermedias de polielectrolitos. En los films multicapa resultantes se desarrolla una reacci\u00f3n enzim\u00e1tica secuencial, con la conversi\u00f3n inicial de glucosa a \u00e1cido gluc\u00f3nico y per\u00f3xido de hidr\u00f3geno, catalizada por gox, y la posterior reducci\u00f3n del per\u00f3xido  de hidr\u00f3geno a agua por acci\u00f3n de la hrp.  la naturaleza secuencial de la metodolog\u00eda lbl permite explorar la influencia de diferentes combinaciones de polielectrolitos sobre la inmovilizaci\u00f3n y funcionalidad de los enzimas para distintas configuraciones de multicapas. Una funcionalidad electroqu\u00edmica se integra adicionalmente en estos filsm mediante la incorporaci\u00f3n de un pol\u00edmero redox a la estructura. los centros redox del pol\u00edmero son capaces de intercambiar electrones con los centros activos de la hrp inmovilizada, pero tambi\u00e9n con la superficie de un electrodo. De este modo, los eventos espec\u00edficos que tienen lugar durante la catal\u00edticas enzim\u00e1tica se transducen en una se\u00f1al el\u00e9ctrica. Las part\u00edculas de s\u00edlice nanoestructuradas asumen un doble papel en el sistema final. Por una parte, act\u00faan como sustratos de alta \u00e1rea superficial para la fabricaci\u00f3n de microreactores enzim\u00e1ticos. Por otro lado, los coloides modificados son incluidos en una caja de pol\u00edmero redox e inmovilizados en la superficie de un electrodo, actuando como elementos de construcci\u00f3n para la creaci\u00f3n de nuevos films mutlicomponente. Estas nuevas estructuras de muestran su potencial utilidad como biosensores electroq\u00faimicos integrados para la detecci\u00f3n de glucosa y per\u00f3xido de hidr\u00f3geno.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Colloidal and molecular assemblies for bioengineering applications<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Colloidal and molecular assemblies for bioengineering applications <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Paula Pescador \u00e1lvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Rovira i virgili<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ioanis Katakis<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Rius ferr\u00fas francesc xavier <\/li>\n<li>ricard Garc\u00eda valls (vocal)<\/li>\n<li>edwin Donath (vocal)<\/li>\n<li>torsten Reese (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paula Pescador \u00e1lvarez En el presente trabajo se emplea la t\u00e9cnica de autoensamblaje capa por capa (layer-by-layer, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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