{"id":62237,"date":"2018-03-09T22:50:06","date_gmt":"2018-03-09T22:50:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-biologica-de-los-sa%c2%adndromes-linfoproliferativos-cronicos-b-desde-la-lesion-genetica-al-ambiente-tumoral\/"},"modified":"2018-03-09T22:50:06","modified_gmt":"2018-03-09T22:50:06","slug":"caracterizacion-biologica-de-los-sa%c2%adndromes-linfoproliferativos-cronicos-b-desde-la-lesion-genetica-al-ambiente-tumoral","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/oncologia\/caracterizacion-biologica-de-los-sa%c2%adndromes-linfoproliferativos-cronicos-b-desde-la-lesion-genetica-al-ambiente-tumoral\/","title":{"rendered":"Caracterizaci\u00f3n biol\u00f3gica de los s\u00edndromes linfoproliferativos cr\u00f3nicos b desde la lesi\u00f3n gen\u00e9tica al ambiente tumoral"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sandra Milena Quijano G\u00f3mez <\/strong><\/h2>\n<p>La informaci\u00f3n disponible acerca del impacto de distintas alteraciones cromos\u00f3micas en la tasa proliferativa de distintos s\u00edndromes linfoproliferativos cr\u00f3nicos b (slpc-b), sigue siendo limitada. Adem\u00e1s, desde el punto de vista cl\u00ednico, la infiltraci\u00f3n de snc, es particularmente frecuente en slpc-b de alto riesgo. Nuestro objetivo se centr\u00f3 en analizar la tasa proliferativa de c\u00e9lulas b neopl\u00e1sicas de distintos slpc-b y compararla con la de su contrapartida normal, con el fin de determinar adem\u00e1s, el impacto de las distintas anomal\u00edas citogen\u00e9ticas, en la tasa proliferativa del tumor y el  inmunofenotipo de las c\u00e9lulas b neopl\u00e1sicas en pacientes con leucemia linf\u00e1tica cr\u00f3nica b (llc-b). Adem\u00e1s, realizamos un an\u00e1lisis comparativo de la citometr\u00eda de flujo (cmf) frente a la citolog\u00eda convencional (cc)  para la investigaci\u00f3n de infiltraci\u00f3n neuromen\u00edngea en pacientes con slpc-b agresivos. Nuestros resultados muestran que la tasa proliferativa de las c\u00e9lulas b neopl\u00e1sicas de slpc-b, se asocia con el estadio madurativo de las c\u00e9lulas tumorales y el subtipo diagn\u00f3stico y, en el caso de la llc-b y el linfoma de c\u00e9lulas del manto, con el tipo de compartimento tisular analizado. Adem\u00e1s, la presencia de aneuplodia de adn en la llc-b y los reordenamientos del gen igh en el linfoma linfoplasmoc\u00edtico\/macroglobulinemia de waldenstr\u00ed\u00b4m, se asocian con mayor actividad proliferativa. Existe una mayor frecuencia de alteraciones gen\u00e9ticas en las llc-b at\u00edpicas, asociada a la presencia de trisom\u00eda 12 y del(17p). Aunque, se observa una asociaci\u00f3n clara entre los perfiles fenot\u00edpicos y las alteraciones citogen\u00e9ticas analizadas, estas no permiten discriminar de forma eficaz entre pacientes con llc-b cuyas c\u00e9lulas b neopl\u00e1sicas muestran distintos patrones de alteraciones gen\u00e9ticas. La cmf tiene una sensibilidad superior que la cc para la detecci\u00f3n de c\u00e9lulas b neopl\u00e1sicas en lcr. Adem\u00e1s, en los pacientes con linfoma de burkitt y linfoma folicular transformado, la presencia de infiltraci\u00f3n a nivel de snc detectada mediante cmf, puede ser predecida con elevada especificidad basada en la coexistencia de niveles s\u00e9ricos elevados de beta2-microglobulina y la presencia de s\u00edntomas neurol\u00f3gicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n biol\u00f3gica de los s\u00edndromes linfoproliferativos cr\u00f3nicos b desde la lesi\u00f3n gen\u00e9tica al ambiente tumoral<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n biol\u00f3gica de los s\u00edndromes linfoproliferativos cr\u00f3nicos b desde la lesi\u00f3n gen\u00e9tica al ambiente tumoral <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sandra Milena Quijano G\u00f3mez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Alberto Orfao De Matos Correia E Vale<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eulogio Conde garcia <\/li>\n<li>Carlos Montalban sanz (vocal)<\/li>\n<li>josep Mar\u00eda Ribera santasusana (vocal)<\/li>\n<li>marcos Gonzalez diaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sandra Milena Quijano G\u00f3mez La informaci\u00f3n disponible acerca del impacto de distintas alteraciones cromos\u00f3micas en la tasa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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