{"id":62279,"date":"2018-03-09T22:50:10","date_gmt":"2018-03-09T22:50:10","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-involucrados-en-la-regulacion-del-tono-vascular-hepatico-en-la-cirrosis-papel-de-los-prostanoides-vasoconstrictores-y-del-estres-oxidativo\/"},"modified":"2018-03-09T22:50:10","modified_gmt":"2018-03-09T22:50:10","slug":"mecanismos-involucrados-en-la-regulacion-del-tono-vascular-hepatico-en-la-cirrosis-papel-de-los-prostanoides-vasoconstrictores-y-del-estres-oxidativo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/mecanismos-involucrados-en-la-regulacion-del-tono-vascular-hepatico-en-la-cirrosis-papel-de-los-prostanoides-vasoconstrictores-y-del-estres-oxidativo\/","title":{"rendered":"Mecanismos involucrados en la regulacion del tono vascular hepatico en la cirrosis: papel de los prostanoides vasoconstrictores y del estres oxidativo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jorge Gracia Sancho <\/strong><\/h2>\n<p>Estudios previos han demostrado que prostanoides vasoconstrictores derivados del \u00e1cido araquid\u00f3nico (aa) por acci\u00f3n de la enzima ciclooxigenasa-1 (cox-1) son parcialmente responsables de la regulaci\u00f3n del tono vascular intrahep\u00e1tico en la cirrosis. Adem\u00e1s, se ha sugerido que las c\u00e9lulas endoteliales sinusoidales (ces) ser\u00edan las responsables de la s\u00edntesis de estos prostanoides. en el primer estudio de esta tesis doctoral se evalu\u00f3 el efecto de una elevada disponibilidad de aa sobre la modulaci\u00f3n del tono vascular intrahep\u00e1tico en la cirrosis y sobre la s\u00edntesis de prostanoides por parte de ces. Adem\u00e1s se estudi\u00f3 el estado molecular de la prote\u00edna responsables de la liberaci\u00f3n intracelular de aa, la fosfolipasa a2.  diferentes estudios han demostrado que elevados niveles de estr\u00e9s oxidativo participan en el desarrollo y transcurso de diferentes hepatopat\u00edas como el s\u00edndrome de isquemia resperfusi\u00f3n o las hepatitis alcoh\u00f3lica y no alcoh\u00f3lica. Adem\u00e1s, en modelos experimentales de enfermedades cardiovasculares, elevados niveles de radicales libres de ox\u00edgeno se han descrito como importantes secuestradotes de la mol\u00e9cula vasodilatadora \u00f3xido n\u00edtrico (on).  la segunda parte de la tesis se centr\u00f3 en la caracterizaci\u00f3n de los niveles de estr\u00e9s oxidativo(incluyendo cuales son sus posibles fuentes) y su posible relaci\u00f3n con un descenso en la cantidad de on intrahep\u00e1tico. Adem\u00e1s, uno de los enzimas m\u00e1s ampliamente descrito como generador de estr\u00e9s oxidatico, la nadph oxidasa, fue caracterizado y su posible papel regulando  el tono vascular introhep\u00e1tico en la cirrosis fue evaluado.  el conjunto de estudios presentados en esta tesis doctoral han sido publicados en las revistas: &#8211;\tjournal of hepatology &#8211;\tgastroenterology &#8211;\thepatology  la presente tesis doctoral est\u00e1 redactada en catal\u00e1n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos involucrados en la regulacion del tono vascular hepatico en la cirrosis: papel de los prostanoides vasoconstrictores y del estres oxidativo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos involucrados en la regulacion del tono vascular hepatico en la cirrosis: papel de los prostanoides vasoconstrictores y del estres oxidativo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jorge Gracia Sancho <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/12\/2007<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Carlos Garcia Pagan<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: agust\u00edn Albillos mart\u00ednez <\/li>\n<li>ramon Bataller alberola (vocal)<\/li>\n<li>joan Rosello catafau (vocal)<\/li>\n<li>daniel Closa autet (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jorge Gracia Sancho Estudios previos han demostrado que prostanoides vasoconstrictores derivados del \u00e1cido araquid\u00f3nico (aa) por acci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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