{"id":62409,"date":"2018-03-09T22:50:17","date_gmt":"2018-03-09T22:50:17","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-las-va%c2%adas-de-senalizacion-intracelulares-implicadas-en-el-ciclo-infectivo-del-virus-de-la-peste-porcina-africana\/"},"modified":"2018-03-09T22:50:17","modified_gmt":"2018-03-09T22:50:17","slug":"estudio-de-las-va%c2%adas-de-senalizacion-intracelulares-implicadas-en-el-ciclo-infectivo-del-virus-de-la-peste-porcina-africana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-de-las-va%c2%adas-de-senalizacion-intracelulares-implicadas-en-el-ciclo-infectivo-del-virus-de-la-peste-porcina-africana\/","title":{"rendered":"Estudio de las v\u00edas de se\u00f1alizaci\u00f3n intracelulares implicadas en el ciclo infectivo del virus de la peste porcina africana."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Quetglas Mas Jos\u00e9 Ignacio <\/strong><\/h2>\n<p>El virus de la peste porcina africana (vppa) causa una grave enfermedad hemorr\u00e1gica en el ganado poricno. El virus entra en las c\u00e9lulas a trav\u00e9s una endocitosis mediada por receptor. Se transporta hasta la regi\u00f3n perinuclear  gracias a la actividad del complejo motor de la dine\u00edna y a trav\u00e9s de los microt\u00fabulos. Entre las v\u00edas de se\u00f1alizaci\u00f3n intracelular que regulan el estado del citoesqueleto y la v\u00eda endoc\u00edtica encontramos a la familia de las gtpasas rho, la familia de la fosfoinos\u00edtido-3-kinasa (pi3k), la familia de la prote\u00edna kinasa c (pkc) y la familia de las erk\/mapk. La familia de las gtpasas rho precisa para su activaci\u00f3n la incorporaci\u00f3n de un grupo prenilo. Los grupos prenilo se generan en la v\u00eda de s\u00edntesis del colesterol. El estudio de estas cuatro familias en relaci\u00f3n con la endocitosis del vppa y su replicaci\u00f3n, adem\u00e1s del estudio de la implicaci\u00f3n de la v\u00eda de s\u00edntesis del colesterol, arroj\u00f3 los siguientes resultados: para la endocitosis del vppa es necesaria la participaci\u00f3n de prote\u00ednas celulares que incorporan un grupo prenilo geranilgeranilo. Para la replicaci\u00f3n del virus es necesaria la participaci\u00f3n de prote\u00ednas celulares que incorporan un grupo prenilo y la integridad de la ruta de s\u00edntesis del colesterol. Las gtpasas de la familia rho no participan en la entrada del vppa. Sin embargo durante su endocitosis se activa rac1. Esta activaci\u00f3n resulta esencial para la correcta morfog\u00e9nesis de los nuevos viriones. La formaci\u00f3n de filopodios durante la exocitosis de los viriones parace estar regulada por las gtpasas rho. Durante la entrada del vppa se activa tambi\u00e9n la gtpasa rap1. Por \u00faltimo, las familias de la pi3k y de la pkc est\u00e1n implicadas en la endocitosis del virus mientras que el concurso de la familia de las erk\/mapk es necesario para la replicaci\u00f3n del virus.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de las v\u00edas de se\u00f1alizaci\u00f3n intracelulares implicadas en el ciclo infectivo del virus de la peste porcina africana.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de las v\u00edas de se\u00f1alizaci\u00f3n intracelulares implicadas en el ciclo infectivo del virus de la peste porcina africana. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Quetglas Mas Jos\u00e9 Ignacio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/01\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Alonso Mart\u00ed Carmen Covadonga<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda no Esteban rodriguez <\/li>\n<li>enrique Tabares lopez (vocal)<\/li>\n<li>esteban Domingo solans (vocal)<\/li>\n<li>carmen Rivas v\u00e1zquez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Quetglas Mas Jos\u00e9 Ignacio El virus de la peste porcina africana (vppa) causa una grave enfermedad hemorr\u00e1gica [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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