{"id":62460,"date":"2018-03-09T22:50:21","date_gmt":"2018-03-09T22:50:21","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/synthesis-and-evaluation-of-cyclic-cationic-peptides-as-antimicrobial-agents-for-use-in-plant-protection\/"},"modified":"2018-03-09T22:50:21","modified_gmt":"2018-03-09T22:50:21","slug":"synthesis-and-evaluation-of-cyclic-cationic-peptides-as-antimicrobial-agents-for-use-in-plant-protection","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica-organica\/synthesis-and-evaluation-of-cyclic-cationic-peptides-as-antimicrobial-agents-for-use-in-plant-protection\/","title":{"rendered":"Synthesis and evaluation of cyclic cationic peptides as antimicrobial agents for use in plant protection"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sylvie Monroc <\/strong><\/h2>\n<p>Esta tesis doctoral se centra en el estudio de la aplicaci\u00f3n de p\u00e9ptidos c\u00edclicos antimicrobianos en la lucha contra agentes pat\u00f3genos de cultivos de plantas de inter\u00e9s econ\u00f3mico. Concretamente, esta tesis doctoral tiene como objetivo el estudio de la aplicaci\u00f3n de p\u00e9ptidos c\u00edclicos de 4-10 amino\u00e1cidos, alternando residuos hidrof\u00edlicos (lisina) e hidrof\u00f3bicos (leucina y fenilalanine), en el control de las enfermedades causadas por las bacterias erwinia amylovora, pseudomonas syringae y xanthomonas vesicatoria. Estas bacterias son responsables de graves enfermedades que afectan cultivos de amplia implantaci\u00f3n e impacto econ\u00f3mico en nuestro pa\u00eds y para las cuales no se han encontrado, hasta ahora, medios qu\u00edmicos o bacteriol\u00f3gicos suficientemente efectivos. Los p\u00e9ptidos estudiados presentan como f\u00f3rmula general: c(xn-y-xm-gln), donde x = lys o leu, y = l-phe o d-phe, m = n = 1, o m = 3 y n = 0-5.  la s\u00edntesis de estos p\u00e9ptidos se ha realizado en fase s\u00f3lida utilizando synphasetm lanterns o resina como soporte s\u00f3lido. Se ha seguido una estrategia tridimensional ortogonal fmoc\/tbut\/al y ha sido necesaria la b\u00fasqueda de las condiciones \u00f3ptimas para las etapas de eliminaci\u00f3n del grupo alilo y de ciclaci\u00f3n. el screening de los p\u00e9ptidos se ha realizado en soluci\u00f3n, una vez escindidos del soporte s\u00f3lido, mediante t\u00e9cnicas in vitro frente a los diferentes tipos de indicadores pat\u00f3genos vegetales. Los ensayos consisten en determinar la actividad inhibidora del crecimiento utilizando un sistema automatizado bioscreen ii (labsystems). Tambi\u00e9n se ha determinado su actividad hemol\u00edtica. de los p\u00e9ptidos c\u00edclicos de 4-10 amino\u00e1cidos sintetizados, el decap\u00e9ptido c(lys-leu-lys-leu-lys-phe-lys-lys-leu-gln) ha resultado ser el m\u00e1s efectivo y se ha tomado como base para el dise\u00f1o de una quimioteca de 56 p\u00e9ptidos. Los resultados de actividad obtenidos han indicado que los compuestos que presentan la estructura general c(x1-x2-x3-x4-lys-phe-lys-l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Synthesis and evaluation of cyclic cationic peptides as antimicrobial agents for use in plant protection<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Synthesis and evaluation of cyclic cationic peptides as antimicrobial agents for use in plant protection <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sylvie Monroc <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Girona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/01\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Eduard Bardaj\u00ed Rodr\u00edguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Francisco Marcos L\u00f3pez <\/li>\n<li>Anna Bonaterra Carreras (vocal)<\/li>\n<li>Muriel Amblard (vocal)<\/li>\n<li>Jaume Camps Soler (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sylvie Monroc Esta tesis doctoral se centra en el estudio de la aplicaci\u00f3n de p\u00e9ptidos c\u00edclicos antimicrobianos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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