{"id":62588,"date":"2018-03-09T22:50:28","date_gmt":"2018-03-09T22:50:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-total-de-nuevas-quinazolinas-y-quinolinas\/"},"modified":"2018-03-09T22:50:28","modified_gmt":"2018-03-09T22:50:28","slug":"sintesis-total-de-nuevas-quinazolinas-y-quinolinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/santiago-de-compostela\/sintesis-total-de-nuevas-quinazolinas-y-quinolinas\/","title":{"rendered":"Sintesis total de nuevas quinazolinas y quinolinas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Manuel Martinez Viturro <\/strong><\/h2>\n<p>En vista del inter\u00e9s biol\u00f3gico de las quinazolinas y las quinolinas, y en el contexto de un proyecto de investigaci\u00f3n establecido con la empresa farmac\u00e9utica janssen-cilag, s.A., Se planteo la s\u00edntesis de una amplia variedad de nuevas estructuras con potencial actividad farmacol\u00f3gica, con el fin de contribuir a la b\u00fasqueda de nuevos lideres o compuestos cabeza de serie.  teniendo en cuenta las aproximaciones sint\u00e9ticas presentes en la bibliograf\u00eda para la obtenci\u00f3n de ambos n\u00facleos, se plantearon como sustratos de partida o-acilanilinas y o-acilaminopiridinas. de esta forma, para la s\u00edntesis de quinazolinas sustituidas en la posici\u00f3n 2 se planteo una ruta cuya etapa clave implica la sustituci\u00f3n nucleofila de 2-cloroquinazolinas con reactivos carbonados y nitrogenados.  para la s\u00edntesis de quinazolinas fusionadas con ciclos de 5 y 6 miembros a trav\u00e9s de las posiciones 2 y 3 (enlace b del n\u00facleo de quinazolina), la etapa clave fue la introducci\u00f3n de una imida mediante reacci\u00f3n de mitsunobu sobre un alcohol bencilico seguida de una reacci\u00f3n de ciclodeshidataci\u00f3n, intramolecular entre la amina y uno de los carbonilos de la imida.  por \u00faltimo, para la s\u00edntesis de quinolinas sustituidas en las posiciones 2 y 7 se utilizo la reacci\u00f3n de fr\u00ed\u00abdlander entre estas o-acilanilinas (y o-acilaminopiridinas ) y diferentes compuestos cet\u00f3nicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis total de nuevas quinazolinas y quinolinas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis total de nuevas quinazolinas y quinolinas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Manuel Martinez Viturro <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/01\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Domingo Dominguez Francisco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Suau suarez <\/li>\n<li>Javier Fernandez gadea (vocal)<\/li>\n<li>pelayo Camps Garc\u00eda (vocal)<\/li>\n<li>paloma Ballesteros Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Manuel Martinez Viturro En vista del inter\u00e9s biol\u00f3gico de las quinazolinas y las quinolinas, y en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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