{"id":62603,"date":"2018-03-09T22:50:28","date_gmt":"2018-03-09T22:50:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modelling-of-5-ht2c-receptors-and-of-their-complexes-with-actual-and-potential-antipsychotic-drugs\/"},"modified":"2018-03-09T22:50:28","modified_gmt":"2018-03-09T22:50:28","slug":"modelling-of-5-ht2c-receptors-and-of-their-complexes-with-actual-and-potential-antipsychotic-drugs","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/modelling-of-5-ht2c-receptors-and-of-their-complexes-with-actual-and-potential-antipsychotic-drugs\/","title":{"rendered":"Modelling of 5-ht2c receptors and of their complexes with actual and potential antipsychotic drugs"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Cristina Dezi <\/strong><\/h2>\n<p>La presente tesis \u00abmodelling of 5-ht2a and 5-ht2c receptors and of their complexes with actual and potential antipsychotic drugs\u00bb tiene como objetivo de profundizar los conocimientos actuales sobre el mecanismo de acci\u00f3n de los f\u00e1rmacos antipsic\u00f3ticos. En este proyecto de larga duraci\u00f3n, se han construidos modelos computacionales de los receptores 5-ht2a y 5-ht2c, utilizando un nuevo protocolo de modelizaci\u00f3n basado sobre los datos experimentales de otras prote\u00ednas gpcr de la misma familia. %&#038;\/Las estructuras 3d se han validado e utilizado en estudios de acoplamiento ligando-receptor, simulaciones de din\u00e1mica molecular, y estudios 3d-qsar con el ligando natural (serotonina), un agonista inverso bien conocido (ketanserina) y una serie de butyrofenonas con afinidad para ambos subtipos receptoriales. %&#038;\/Las metodolog\u00edas directas e indirectas utilizadas, han permitido de comprender mejor los elementos claves que gobiernan el acoplamiento ligando &#8211; receptor, mediante la identificaci\u00f3n de los residuos m\u00e1s involucrados en esta interacci\u00f3n, el rol de la quiralidad de los ligandos y tambi\u00e9n las posiciones alternativas de acoplamiento que algunos ligandos pueden asumir en el sitio de uni\u00f3n de los receptores.%&#038;\/Los resultados son coherentes con los datos experimentales y su interpretaci\u00f3n ha proporcionado informaci\u00f3n valiosa, dif\u00edcilmente obtenible con la simple inspecci\u00f3n visual de las estructuras de los ligandos y de los receptores.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modelling of 5-ht2c receptors and of their complexes with actual and potential antipsychotic drugs<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modelling of 5-ht2c receptors and of their complexes with actual and potential antipsychotic drugs <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Cristina Dezi <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/01\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ferran Sanz Carreras<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: olga Valverde granados <\/li>\n<li>christian Fern\u00e1ndez masaguer (vocal)<\/li>\n<li>Mar\u00eda  isabel Loza garcia (vocal)<\/li>\n<li>jordi Rodrigo de losada (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cristina Dezi La presente tesis \u00abmodelling of 5-ht2a and 5-ht2c receptors and of their complexes with actual [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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