{"id":62737,"date":"2008-01-02T00:00:00","date_gmt":"2008-01-02T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/chromatin-alterations-imposed-by-the-oncogenic-transcription-factor-pml-raralfa\/"},"modified":"2008-01-02T00:00:00","modified_gmt":"2008-01-02T00:00:00","slug":"chromatin-alterations-imposed-by-the-oncogenic-transcription-factor-pml-raralfa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/chromatin-alterations-imposed-by-the-oncogenic-transcription-factor-pml-raralfa\/","title":{"rendered":"Chromatin alterations imposed by the oncogenic transcription factor pml-raralfa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Llu\u00eds Morey Ramonell <\/strong><\/h2>\n<p>En mam\u00edferos, as\u00ed como en plantas, mutaciones en and helicasas\/atpasas del la fam\u00edlia snf2, no solo afectan a la estructura de la cromatina, sino que tambi\u00e9n afectan al patr\u00f3n global de la metilaci\u00f3n del adn. Sugiriendo una relaci\u00f3n funcional entre la estructura de la cromatina y la epigen\u00e9tica. El complejo nurd, el cual posee una atpasa de la famil\u00eda snf2, est\u00e1 relacionado con la represi\u00f3n de la transcripci\u00f3n y en el remodelamiento de la cromatina. Nuestro laboratorio demostr\u00f3 que la prote\u00edna leuc\u00e9mica pml-rara reprime la transcripci\u00f3n de sus genes diana por el reclutamiento de dnmts y el complejo prc2. En esta tesis, demostramos una relaci\u00f3n directa del complejo nurd en la represi\u00f3n g\u00e9nica y en los cambios epigen\u00e9ticos en la leucemia promieloc\u00edtica aguda (apl). Mostramos que pml-rara se une y recluta nurd a sus genes diana, incluyendo el gen supresor de tumores rarb2, facilitando que el complejo de polycomb se reclute y metile la lisina 27 de la histona h3. Tratamiento con acido retin\u00f3ico (ra), el qual se utiliza en pacientes, reduce la ocupaci\u00f3n de nurd en c\u00e9lulas leuc\u00e9micas. Eliminando nurd no solo provoca que las histonas no se deacetilen  y que la cromatina no se compacte, sino que tambi\u00e9n provoca que tanto la metilaci\u00f3n del adn y de las histonas no se produzca, as\u00ed como la represi\u00f3n g\u00e9nica del gen rarb2, favoreciendo la diferenciaci\u00f3n celular. Nuestros resultados caracterizan un nuevo papel del complejo nurd en el establecimiento de los patrones epigen\u00e9ticos en apl, demostrando una relaci\u00f3n esencial entre la estructura de la cromatina y epigen\u00e9tica durante el desarrollo de la leucemia, pudi\u00e9ndose aplicar a la terapia de esta enfermedad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Chromatin alterations imposed by the oncogenic transcription factor pml-raralfa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Chromatin alterations imposed by the oncogenic transcription factor pml-raralfa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Llu\u00eds Morey Ramonell <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/02\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luciano Di Croce<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Garcia de herreros madue\u00f1o <\/li>\n<li>salvador Aznar benitah (vocal)<\/li>\n<li>albert Jordan valles (vocal)<\/li>\n<li>Miguel angel Peinado morales (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Llu\u00eds Morey Ramonell En mam\u00edferos, as\u00ed como en plantas, mutaciones en and helicasas\/atpasas del la fam\u00edlia snf2, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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