{"id":6275,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/mecanismos-bioquimicos-de-accion-de-un-nuevo-agente-antiplaquetario-pca-4230\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"mecanismos-bioquimicos-de-accion-de-un-nuevo-agente-antiplaquetario-pca-4230","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/mecanismos-bioquimicos-de-accion-de-un-nuevo-agente-antiplaquetario-pca-4230\/","title":{"rendered":"Mecanismos bioquimicos de accion de un nuevo agente antiplaquetario (pca-4230)."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Lombardia Uria <\/strong><\/h2>\n<p>Este trabajo se ha centrado en el estudio, como posible agente terapeutico, de un nuevo derivado de 1,4-dihidropiridina con actividad antiplaquetaria, el pca-4230, habiendose establecido como objetivos el estudio de su modo de accion bioquimico y la valoracion de sus efectos sobre los mecanismos bioquimicos de activacion plaquetaria. El resultado fue que el pca-4230 se comporto como un inhibidor selectivo de la fosfodiesterasa de gmp ciclico provocando un incremento en los niveles intraplaquetarios del mismo afectando, principalmente a las vias metabolicas relacionadas con el calcio ya que se observo la inhibicion de la movilizacion del mismo de la activacion de la quinasa de la cadena ligera de la miosina, de la fosfolipasa a2, conduciendo todo ello a la reduccion de la activacion plaquetaria reflejada en una inhibicion de los fenomenos de secrecion y agregacion plaquetaria.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos bioquimicos de accion de un nuevo agente antiplaquetario (pca-4230).<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos bioquimicos de accion de un nuevo agente antiplaquetario (pca-4230). <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Lombardia Uria <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ana Martinez Diaz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  Monica De La Fuente Del Rey <\/li>\n<li> Fernandez Santaren Juan  Antonio (vocal)<\/li>\n<li>Edgardo Catalan Tobar (vocal)<\/li>\n<li>Carlos Sunkel Letecier (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Lombardia Uria Este trabajo se ha centrado en el estudio, como posible agente terapeutico, de un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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