{"id":62990,"date":"2018-03-09T22:50:55","date_gmt":"2018-03-09T22:50:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-experimental-del-papel-de-la-senalizacion-por-factores-de-crecimiento-durante-las-fases-iniciales-del-desarrollo-del-corazon\/"},"modified":"2018-03-09T22:50:55","modified_gmt":"2018-03-09T22:50:55","slug":"analisis-experimental-del-papel-de-la-senalizacion-por-factores-de-crecimiento-durante-las-fases-iniciales-del-desarrollo-del-corazon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/biologia-celular\/analisis-experimental-del-papel-de-la-senalizacion-por-factores-de-crecimiento-durante-las-fases-iniciales-del-desarrollo-del-corazon\/","title":{"rendered":"An\u00e1lisis experimental del papel de la se\u00f1alizaci\u00f3n por factores de crecimiento durante las fases iniciales del desarrollo del coraz\u00f3n"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Natividad Garc\u00eda Masa <\/strong><\/h2>\n<p>Resumen: en la presente tesis doctoral describimos un estudio detallado de la diferenciaci\u00f3n y compromiso de las c\u00e9lulas precardiacas localizadas a nivel de la l\u00ednea primitiva. La mayor\u00eda de las c\u00e9lulas correspondientes a los segmentos rostrales de la l\u00ednea primitiva contribuyen a formar la capa de endodermo adyacente al mesodermo precardiaco, formado a su vez a partir de las c\u00e9lulas y la expresi\u00f3n de sus marcadores card\u00edacos espec\u00edficos (cnkx2.5, bmp2, cripto, usmaar, dhand, gata4, pitx2, hex, fgf8). Proponemos que las c\u00e9lulas card\u00edacas de la l\u00ednea primitiva est\u00e1n organizadas al menos en dos grupos con diferentes significaci\u00f3n. Uno, regulado posiblemente por el organizador, localizado preferentemente en la regi\u00f3n m\u00e1s rostral de la l\u00ednea primitiva. Est\u00e1 constituido por las c\u00e9lulas prospectivas de la capa endod\u00e9rmica, con un patr\u00f3n jerarquizado de expresi\u00f3n preferentemente en los segmentos m\u00e1s caudales, y su destino es la formaci\u00f3n del mesodermo precardiaco, cuya diferenciaci\u00f3n se caracterizar\u00eda por la expresi\u00f3n de varios genes espec\u00edficos. Previamente se ha sugerido que bmp2, el cual se expresa a nivel del endodermo subyacente al mesodermo precardiaco, es requerido para la expresi\u00f3n precoz del factor de transcripci\u00f3n cnkx2.5. Adem\u00e1s, bmp2 induce la expresi\u00f3n de fgf8, gata4 y hex. En un intento de aportar nuevos datos sobre la se\u00f1alizaci\u00f3n que regula la cardiog\u00e9nesis, nosotros analizamos el papel de fgf8 y fgf4 sobre la expresi\u00f3n de genes cardiacos, mediante electroporaci\u00f3n in vitro y administraci\u00f3n de esferas acr\u00edlicas de heparina. Nuestros resultados muestran que la sobreexpresi\u00f3n de los fgfs sobre las c\u00e9lulas precard\u00edacas disminuye la expresi\u00f3n de cnkx2.5, problamente por la disminuci\u00f3n de bmp2. Podr\u00eda plantearse la hip\u00f3tesis que durante la cardiog\u00e9nesis bmp2 induce a fgf8, y los niveles elevados de fgf8 inhibir\u00edan a bmp2, estableciendo un mecanismo de retroalimentaci\u00f3n negativa que determinar\u00eda el final de la cardiog\u00e9nesis y permitir\u00eda el inicio de la mofog\u00e9nesis de los tubos enoc\u00e1rdicos primitivos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis experimental del papel de la se\u00f1alizaci\u00f3n por factores de crecimiento durante las fases iniciales del desarrollo del coraz\u00f3n<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis experimental del papel de la se\u00f1alizaci\u00f3n por factores de crecimiento durante las fases iniciales del desarrollo del coraz\u00f3n <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Natividad Garc\u00eda Masa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Extremadura<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/02\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen L\u00f3pez S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  mario Hurle gonzalez <\/li>\n<li>Jos\u00e9 ramon Sa\u00f1udo tejero (vocal)<\/li>\n<li>damian Sanchez quintana (vocal)<\/li>\n<li>ignacio Santiago Alvarez Miguel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Natividad Garc\u00eda Masa Resumen: en la presente tesis doctoral describimos un estudio detallado de la diferenciaci\u00f3n y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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