{"id":63074,"date":"2018-03-09T22:50:59","date_gmt":"2018-03-09T22:50:59","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/terapia-combinada-contra-la-leucemia-mastoca%c2%adtica-aguda-basada-en-la-inhibicion-del-proto-oncogen-c-kit-y-el-tratamiento-con-tocoferol-succinato\/"},"modified":"2018-03-09T22:50:59","modified_gmt":"2018-03-09T22:50:59","slug":"terapia-combinada-contra-la-leucemia-mastoca%c2%adtica-aguda-basada-en-la-inhibicion-del-proto-oncogen-c-kit-y-el-tratamiento-con-tocoferol-succinato","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/terapia-combinada-contra-la-leucemia-mastoca%c2%adtica-aguda-basada-en-la-inhibicion-del-proto-oncogen-c-kit-y-el-tratamiento-con-tocoferol-succinato\/","title":{"rendered":"Terapia combinada contra la leucemia mastoc\u00edtica aguda basada en la inhibici\u00f3n del proto-oncog\u00e9n c-kit y el tratamiento con tocoferol succinato"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Irene Ruano Solana <\/strong><\/h2>\n<p>El arn de interferencia se ha convertido en una estrategia excelente para el silenciamiento de la expresi\u00f3n de genes. Usando retrovirus portadores de las secuencias de adn transcribibles a arn de interferencia contra los mensajeros del receptor c-kit, se ha encontrado que tanto la inhibici\u00f3n del mensajero mutado de c-kit como la inhibici\u00f3n de ambos mensajeros mutado y silvestre, reduce la proliferaci\u00f3n incontrolada de las c\u00e9lulas de leucemia mastoc\u00edtica aguda humana, causada por la activaci\u00f3n constitutiva de dicho receptor. La combinaci\u00f3n de dicho tratamiento de la leucemia mastoc\u00edtica aguda humana con toceferol succinato, ha potenciado de forma significativa la terapia antitumoral, estableci\u00e9ndose esta \u00faltima como un tratamiento alternativo frente a inhibidores farmacol\u00f3gicos de kit como gleevec que no son capaces de reducir la supervivencia de las c\u00e9lulas de leucemia mastoc\u00edtica aguda que presentan la mutaci\u00f3n asp816val.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Terapia combinada contra la leucemia mastoc\u00edtica aguda basada en la inhibici\u00f3n del proto-oncog\u00e9n c-kit y el tratamiento con tocoferol succinato<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Terapia combinada contra la leucemia mastoc\u00edtica aguda basada en la inhibici\u00f3n del proto-oncog\u00e9n c-kit y el tratamiento con tocoferol succinato <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Irene Ruano Solana <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/02\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Marta Izquierdo Rojo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 manuel Sierra p\u00e9rez <\/li>\n<li>Luis Escribano mora (vocal)<\/li>\n<li>ricardo L\u00f3pez p\u00e9rez (vocal)<\/li>\n<li>silvia anna Ciafre (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Irene Ruano Solana El arn de interferencia se ha convertido en una estrategia excelente para el silenciamiento [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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