{"id":63203,"date":"2018-03-09T22:51:06","date_gmt":"2018-03-09T22:51:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/secrecion-de-protea%c2%adnas-heterologas-en-aspergillus-awamori-funcion-de-las-protea%c2%adnas-bip-y-pdi\/"},"modified":"2018-03-09T22:51:06","modified_gmt":"2018-03-09T22:51:06","slug":"secrecion-de-protea%c2%adnas-heterologas-en-aspergillus-awamori-funcion-de-las-protea%c2%adnas-bip-y-pdi","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/secrecion-de-protea%c2%adnas-heterologas-en-aspergillus-awamori-funcion-de-las-protea%c2%adnas-bip-y-pdi\/","title":{"rendered":"Secreci\u00f3n de prote\u00ednas heter\u00f3logas en aspergillus awamori: funci\u00f3n de las prote\u00ednas bip y pdi"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Lombra\u00f1a Tasc\u00f3n <\/strong><\/h2>\n<p>Uno de los principales atractivos de los hongos se basa en su gran capacidad secretora de distintos enzimas y metabolitos secundarios. A pesar de que las caracter\u00edsticas de los hongos filamentosos les convierten en hospedadores id\u00f3neos para la producci\u00f3n de prote\u00ednas heter\u00f3logas, los niveles de secreci\u00f3n de estas prote\u00ednas en estos organismos suelen ser bastante inferiores a los observados para las prote\u00ednas hom\u00f3logas, lo que pone de manifiesto que existen distintos cuellos de botella a lo largo de su ruta secretora. Para solventar algunas de las limitaciones que existen a nivel (post)-traduccional para la secreci\u00f3n de prote\u00ednas heter\u00f3logas se utiliza, entre otras estrategias, la manipulaci\u00f3n de los niveles de chaperonas y foldasas del re. En el presente trabajo se estudiaron los efectos de las prote\u00ednas bip y pdi sobre la secreci\u00f3n de determinadas prote\u00ednas hom\u00f3logas y heter\u00f3logas en a. Awamori, as\u00ed como el efecto del estr\u00e9s en estas prote\u00ednas de la ruta secretora. la sobreexpresi\u00f3n del gen bipa de a. Awamori provoca un aumento en la secreci\u00f3n de la prote\u00edna heter\u00f3loga taumatina. Adem\u00e1s, parece existir un nivel \u00f3ptimo de expresi\u00f3n del gen bipa con el que se alcanzan los m\u00e1ximos niveles de secreci\u00f3n de la prote\u00edna heter\u00f3loga taumatina. la atenuaci\u00f3n del gen bipa provoca una disminuci\u00f3n en la cantidad de taumatina secretada. las prote\u00ednas hom\u00f3logas  -amilasa y glucoamilasa no parecen verse afectadas ni por la sobreexpresi\u00f3n ni por la atenuaci\u00f3n de la expresi\u00f3n del gen bipa. la sobreexpresi\u00f3n del gen de la prote\u00edna heter\u00f3loga taumatina en a. Awamori, provoca una respuesta upr que se traduce en un aumento de los niveles de expresi\u00f3n de los genes bipa y pdia, respecto a los niveles observados en cepas no recombinantes. la principal actividad de la pdia de a. Awamori para la correcta secreci\u00f3n de la prote\u00edna heter\u00f3loga taumatina, parece ser la actividad prote\u00edna-isomerasa. la sobreexpresi\u00f3n conjunta de los genes bipa<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Secreci\u00f3n de prote\u00ednas heter\u00f3logas en aspergillus awamori: funci\u00f3n de las prote\u00ednas bip y pdi<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Secreci\u00f3n de prote\u00ednas heter\u00f3logas en aspergillus awamori: funci\u00f3n de las prote\u00ednas bip y pdi <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Lombra\u00f1a Tasc\u00f3n <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/02\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Francisco Mart\u00edn Mart\u00edn<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Rey iglesias <\/li>\n<li>peter Maccabe andrew (vocal)<\/li>\n<li>Antonio Villaverde corrales (vocal)<\/li>\n<li>Fernando Leal sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Lombra\u00f1a Tasc\u00f3n Uno de los principales atractivos de los hongos se basa en su gran capacidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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