{"id":63275,"date":"2008-04-03T00:00:00","date_gmt":"2008-04-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/polimorfismo-hnmt-histaminia-n-metil-transferasa-en-el-riesgo-para-el-desarrollo-de-migrana\/"},"modified":"2008-04-03T00:00:00","modified_gmt":"2008-04-03T00:00:00","slug":"polimorfismo-hnmt-histaminia-n-metil-transferasa-en-el-riesgo-para-el-desarrollo-de-migrana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/elementos-minerales-en-la-alimentacion\/polimorfismo-hnmt-histaminia-n-metil-transferasa-en-el-riesgo-para-el-desarrollo-de-migrana\/","title":{"rendered":"Polimorfismo hnmt (histaminia-n-metil-transferasa) en el riesgo para el desarrollo de migra\u00f1a"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mercedes Serrador Garcia <\/strong><\/h2>\n<p>La histamina est\u00e1 implicada en la fisiopatogenia de la migra\u00f1a. En el sistema nervioso central, la histamina, pr\u00e1cticamente metabolizada por le enzima histamina n-metil-transferasa. El gen hnmt (cromosoma 2q22.1) presenta diversos polimorfismos de nucle\u00f3tido simple, uno de ellos, localizado en el ex\u00f3n 4 c314t provoca la sustituci\u00f3n del amino\u00e1cido thr105ile, que provoca la disminuci\u00f3n de su actividad enzim\u00e1tica. en el presente estudio se ha investigado la posible asociaci\u00f3n entre los genotipos hnmt y las variantes al\u00e9licas en 197 pacientes con migra\u00f1a y 245 controles mediante el uso del m\u00e9todo pcr-rflp. en el an\u00e1lisis de las frecuencias de los genotipos hnmt y de las variantes al\u00e9licas no se encontraron diferencia significativas entre los pacientes migra\u00f1osos y los controles; dichas frecuencias tampoco se mostraron influidas por la edad de inicio de la migra\u00f1a (<16a\u00f1os vs.>15 a\u00f1os), ni por la presencia o no de historia familiar de migra\u00f1a, ni por la historia personal de enfermedades al\u00e9rgicas, ni por la presencia o no de aura durante el episodio migra\u00f1oso. en conclusi\u00f3n, el polimorfismo gen\u00e9tico hnmt parece no tener relaci\u00f3n don el riesgo de padecer migra\u00f1a.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Polimorfismo hnmt (histaminia-n-metil-transferasa) en el riesgo para el desarrollo de migra\u00f1a<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Polimorfismo hnmt (histaminia-n-metil-transferasa) en el riesgo para el desarrollo de migra\u00f1a <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mercedes Serrador Garcia <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/03\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Felix Javier Jim\u00e9nez Jim\u00e9nez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: melchor Alvarez de mon soto <\/li>\n<li>Alberto L\u00f3pez de guzm\u00e1n (vocal)<\/li>\n<li>ignacio Arribas g\u00f3mez (vocal)<\/li>\n<li>julio Pascual g\u00f3mez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mercedes Serrador Garcia La histamina est\u00e1 implicada en la fisiopatogenia de la migra\u00f1a. En el sistema nervioso [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,10274],"tags":[127269,19411,22956,33240,14431,139715],"class_list":["post-63275","post","type-post","status-publish","format-standard","hentry","category-alcala","category-elementos-minerales-en-la-alimentacion","tag-alberto-lopez-de-guzman","tag-felix-javier-jimenez-jimenez","tag-ignacio-arribas-gomez","tag-julio-pascual-gomez","tag-melchor-alvarez-de-mon-soto","tag-mercedes-serrador-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/63275","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=63275"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/63275\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=63275"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=63275"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=63275"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}