{"id":63277,"date":"2008-04-03T00:00:00","date_gmt":"2008-04-03T00:00:00","guid":{"rendered":""},"modified":"2008-04-03T00:00:00","modified_gmt":"2008-04-03T00:00:00","slug":"analisis-de-factores-de-riesgo-geneticos-asociados-a-al-nefropata%c2%ada-cronica-del-trasplante-renal-moleculas-de-adhesion-sistema-de-coagulacion-plaquetar-marcadores-de-riesgo-cardiovascular-y-tg","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/nefrologia\/analisis-de-factores-de-riesgo-geneticos-asociados-a-al-nefropata%c2%ada-cronica-del-trasplante-renal-moleculas-de-adhesion-sistema-de-coagulacion-plaquetar-marcadores-de-riesgo-cardiovascular-y-tg\/","title":{"rendered":"An\u00e1lisis de factores de riesgo gen\u00e9ticos asociados a al nefropat\u00edacr\u00f3nica del trasplante renal: mol\u00e9culas de adhesi\u00f3n, sistema de coagulaci\u00f3n-plaquetar, marcadores de riesgo cardiovascular y tgf-beta"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Cobo Caso Mar\u00eda  Angeles <\/strong><\/h2>\n<p>A nefropat\u00eda cr\u00f3nica del trasplante (nct) es la primera causa de p\u00e9rdida de trasplante renal, despu\u00e9s de la muerte del paciente con injerto funcionante. Como en otras enfermedades complejas, es posible que la interacci\u00f3n de factores ambientales y gen\u00e9ticos sea fundamental en su desarrollo. Entre los m\u00faltiples factores involucrados en la nct se encuentran  las mol\u00e9culas de adhesi\u00f3n, sistema de coagulaci\u00f3n, factores de risgo cardiovascular y tgf-beta. Por tanto, polimorfismos gen\u00e9ticos de mol\u00e9culas que componen estos sistemas son excelentes candidatos a estudio. Hasta ahora, los resultados del impacto de factores gen\u00e9ticos en la nct son poco concluyentes, hecho que se justifica por la heterogeneidad en el dise\u00f1o de estos trabajos. Por tanto, es preciso en estos estudios aplicar criterios de validaci\u00f3n similares a los empleados en otras enfermedades complejas. Los objetivos de esta tesis son: objetivo primario: en un estudio de cohortes de todos los pacientes trasplantados renales de la comunidad canaria entre 1996-2003 (673 pacientes) y con un periodo de seguimiento de 1 a 8 a\u00f1os, investigar si existe una relaci\u00f3n independiente entre distintos polimorfismos gen\u00e9ticos de donante y receptor (polimorfismos de mol\u00e9culas de adhesi\u00f3n,   componentes del sistema de coagulaci\u00f3n, marcadores de riesgo cardiovascular y tgf-beta) en el deterioro cr\u00f3nico de la funci\u00f3n del injerto (dcfi) y supervivencia de injerto; objetivos secundarios: 1) determinar si existe asociaci\u00f3n independiente entre estos polimorfismos y la supervivencia del paciente; 2) analizar el efecto independiente de otros factores de riesgo cl\u00e1sicos en el dcfi. La metodolog\u00eda incluy\u00f3 an\u00e1lisi uni y multivariantes incluyendo todas las variables potencialmente relacionadas con el dcfi y supervivencia de injerto y paciente, ajuste de la \u00abp\u00bb para contrastes m\u00faltiples, control del sesgo de estratificaci\u00f3n mediante marcadores neutros y an\u00e1lisi de de posibles haplotipos de riesgo del tgf-beta<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de factores de riesgo gen\u00e9ticos asociados a al nefropat\u00edacr\u00f3nica del trasplante renal: mol\u00e9culas de adhesi\u00f3n, sistema de coagulaci\u00f3n-plaquetar, marcadores de riesgo cardiovascular y tgf-beta<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de factores de riesgo gen\u00e9ticos asociados a al nefropat\u00edacr\u00f3nica del trasplante renal: mol\u00e9culas de adhesi\u00f3n, sistema de coagulaci\u00f3n-plaquetar, marcadores de riesgo cardiovascular y tgf-beta <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Cobo Caso Mar\u00eda  Angeles <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/03\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Armando Torres Ram\u00edrez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Arias rodriguez <\/li>\n<li> Gonz\u00e1lez-posada delgado Jos\u00e9 Manuel (vocal)<\/li>\n<li>domingo Hernandez marrero (vocal)<\/li>\n<li> Fern\u00e1ndez rodr\u00edguez Ana Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Cobo Caso Mar\u00eda Angeles A nefropat\u00eda cr\u00f3nica del trasplante (nct) es la primera causa de p\u00e9rdida de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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