{"id":63455,"date":"2008-12-03T00:00:00","date_gmt":"2008-12-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/metabolismo-oxidativo-en-ninos-y-adolescentes-con-diabetes-mellitus-insulinodependiente-marcadores-precoces-de-dano-a-moleculas-y-nefropata%c2%ada-diabetica-incipiente\/"},"modified":"2008-12-03T00:00:00","modified_gmt":"2008-12-03T00:00:00","slug":"metabolismo-oxidativo-en-ninos-y-adolescentes-con-diabetes-mellitus-insulinodependiente-marcadores-precoces-de-dano-a-moleculas-y-nefropata%c2%ada-diabetica-incipiente","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/metabolismo-oxidativo-en-ninos-y-adolescentes-con-diabetes-mellitus-insulinodependiente-marcadores-precoces-de-dano-a-moleculas-y-nefropata%c2%ada-diabetica-incipiente\/","title":{"rendered":"Metabolismo oxidativo en ni\u00f1os y adolescentes con diabetes mellitus insulinodependiente: marcadores precoces de da\u00f1o a mol\u00e9culas y nefropat\u00edadiab\u00e9tica incipiente"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sara Pons Morales <\/strong><\/h2>\n<p>La diabetes mellitus tipo 1 (dm1), es el trastorno endocrino-metab\u00f3lico m\u00e1s frecuente de la infancia y la adolescencia, con importantes secuelas para el desarrollo f\u00edsico y emocional. Su evoluci\u00f3n viene caracterizada por una serie de complicaciones agudas, como son la hipoglucemia y la cetoacidosi, y otras de presentaci\u00f3n a largo plazo, que en su sintomatolog\u00eda cl\u00ednica van a ser propias del adulto pero que en sus aspectos de prevenci\u00f3n primaria competen directamente al ni\u00f1o y adolescente. Estas complicaciones van a ser de tipo vascular, y en la infancia y adolescencia, lo que predomina fundamentalmente es la microangiopat\u00eda. Aunque puede afectar a todo el lecho vascular, sus principales manifestaciones se derivan de su localizaci\u00f3n en tras \u00f3rganos o sistemas, condicionando la retinopat\u00eda, la neuropat\u00eda y la nefropat\u00eda diab\u00e9ticas (nd). en los pa\u00edses desarrollados, la nd es no s\u00f3lo la principal causa de insuficiencia renal cr\u00f3nica sino la que ha tenido un incremento m\u00e1s acelerado en las dos \u00faltimas d\u00e9cadas. Se estima que, aproximadamente el 30-50% de todos los pacientes con dm1 desarrollar\u00e1n enfermedad renal entre 5 y 15 a\u00f1os despu\u00e9s del inicio de la diabetes. A pesar de carecer de una hip\u00f3tesis unificada que explique la alta incidencia de enfermedad renal en la dm1, se han identificado una serie de factores de riesgo, entre ellos, el mal control metab\u00f3lico, la hta, el aumento del filtrado glomerular (hf) y factores diet\u00e9ticos, adem\u00e1s de la predisposici\u00f3n o carga gen\u00e9tica que representar\u00eda uno de los aspectos esenciales. El da\u00f1o vascular relacionado con la hiperglucemia, es mediado por distintas v\u00edas bioqu\u00edmicas: la v\u00eda de los polioles, la v\u00eda de la hexosamina, la v\u00eda de formaci\u00f3n de productos finales de la glicosilaci\u00f3n (age) y la v\u00eda del diacilglicerol-prote\u00edna c cinasa. El estr\u00e9s oxidativo (eo) se ha implicado en los mecanismos de lesi\u00f3n de la c\u00e9lula \u00edY-pancre\u00e1tica, en la acci\u00f3n de la insulina, en los estados de resis<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Metabolismo oxidativo en ni\u00f1os y adolescentes con diabetes mellitus insulinodependiente: marcadores precoces de da\u00f1o a mol\u00e9culas y nefropat\u00edadiab\u00e9tica incipiente<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Metabolismo oxidativo en ni\u00f1os y adolescentes con diabetes mellitus insulinodependiente: marcadores precoces de da\u00f1o a mol\u00e9culas y nefropat\u00edadiab\u00e9tica incipiente <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sara Pons Morales <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/03\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Roberto Hern\u00e1ndez Marco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan Brines solanes <\/li>\n<li>Antonio Carrascosa lezcano (vocal)<\/li>\n<li>seraf\u00edn M\u00e1laga guerrero (vocal)<\/li>\n<li>Antonio Hern\u00e1ndez mijares (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sara Pons Morales La diabetes mellitus tipo 1 (dm1), es el trastorno endocrino-metab\u00f3lico m\u00e1s frecuente de la 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