{"id":63503,"date":"2018-03-09T22:51:25","date_gmt":"2018-03-09T22:51:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-expresion-y-funcion-de-las-lectinas-mieloides-dc-sign-y-lsectin\/"},"modified":"2018-03-09T22:51:25","modified_gmt":"2018-03-09T22:51:25","slug":"regulacion-de-la-expresion-y-funcion-de-las-lectinas-mieloides-dc-sign-y-lsectin","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-expresion-y-funcion-de-las-lectinas-mieloides-dc-sign-y-lsectin\/","title":{"rendered":"Regulaci\u00f3n de la expresi\u00f3n y funci\u00f3n de las lectinas mieloides dc-sign  y lsectin"},"content":{"rendered":"<h2>Tesis doctoral de <strong> \u00e1ngeles Dom\u00ednguez Soto <\/strong><\/h2>\n<p>Dc-sign y lsectin pertenecen al grupo ii de las lectinas tipo c y ambas est\u00e1n codificadas en el brazo corto del cromosoma 19 (19p13.2). La presente tesis pretende el estudio de la expresi\u00f3n de ambas lectinas, as\u00ed como la caracterizaci\u00f3n estructural y funcional de lsectin. Lsectin (\u00abliver and lymph node sinusoidal endothelial cell c-type lectin\u00bb), aunque descrita anteriormente como una prote\u00edna tipo ii `propia de c\u00e9lulas endoteliales sinusoidales, se expresa en el linaje mieloide, y concretamente en c\u00e9lulas dendr\u00edticas y madr\u00f3fagos aislados ex vivo, as\u00ed como en estas mismas poblaciones generadas in vitro. Adem\u00e1s, en este trabajo se demuestra la inducibilidad por il-4 de al menos tres isoformas generadas mediante procesamiento alternativo. Como parte de la caracterizaci\u00f3n lsectin se analiz\u00f3 el perfil de reconocimiento de az\u00facares y su capacidad para interaccionar con pat\u00f3genos, observ\u00e1ndose que lsectin reconoce n-acetil-glucosamina y funciona como receptor de pat\u00f3genos, ya que su expresi\u00f3n confiere a c\u00e9lulas leuc\u00e9micas la capacidad de unir virus ebola. Adem\u00e1s, la interacci\u00f3n con ligado o anticuerpo espec\u00edfico provoca la internalizaci\u00f3n de la mol\u00e9cula, proceso que depende los motivos tirosina y diglut\u00e1mico presentes en la regi\u00f3n citoplasm\u00e1tica. Por tanto, lsectin, al que dc-sign, puede considerarse como un receptor de patrones moleculares asociados a pat\u00f3genos de c\u00e9lulas mieloides humanas. Por otra parte, ambas lectinas expresas en c\u00e9lulas mieloides est\u00e1n reguladas a nivel transcripcional por el factor pu.1 a trav\u00e9s de la ocupaci\u00f3n de elementos de dna contenidos en sus regiones reguladoras proximales y la colaboraci\u00f3n con otros factores de transcripci\u00f3n hematopoy\u00e9ticos. La expresi\u00f3n de dc-sign y lsectin correlaciona con la de pu.1 en el proceso de maduraci\u00f3n de c\u00e9lulas dendr\u00edticas, as\u00ed como en la activaci\u00f3n alternativa de macr\u00f3fagos. La reducci\u00f3n de los niveles de expresi\u00f3n de pu.1 provocan una disminuci\u00f3n en el mensajero de ambas lectinas. Por todo ello, este trabajo demuestra la implicaci\u00f3n de pu.1 en la expresi\u00f3n mieloide de dc-sign y lsectin, una contribuci\u00f3n acorde con el papel que tiene pu.1 en la adquisici\u00f3n del repertorio molecular de captaci\u00f3n antig\u00e9nica por c\u00e9lulas dendr\u00edticas y macrof\u00e1gos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n de la expresi\u00f3n y funci\u00f3n de las lectinas mieloides dc-sign  y lsectin<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n de la expresi\u00f3n y funci\u00f3n de las lectinas mieloides dc-sign  y lsectin <\/li>\n<li><strong>Autor:<\/strong>\u00a0 \u00e1ngeles Dom\u00ednguez Soto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/03\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Corbi Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cristina Casals carro <\/li>\n<li>Elena Fern\u00e1ndez ruiz (vocal)<\/li>\n<li>Antonio Castrillo viguera (vocal)<\/li>\n<li>Antonio Celada cotarelo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de \u00e1ngeles Dom\u00ednguez Soto Dc-sign y lsectin pertenecen al grupo ii de las lectinas tipo c y ambas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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