{"id":63579,"date":"2018-03-09T22:51:32","date_gmt":"2018-03-09T22:51:32","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-la-hipoxia-cronica-sostenida-e-intermitente-modelos-de-la-enfermedad-pulmonar-obstructiva-cronica-y-del-sa%c2%adndrome-de-apnea-del-sueno-humanos\/"},"modified":"2018-03-09T22:51:32","modified_gmt":"2018-03-09T22:51:32","slug":"efectos-de-la-hipoxia-cronica-sostenida-e-intermitente-modelos-de-la-enfermedad-pulmonar-obstructiva-cronica-y-del-sa%c2%adndrome-de-apnea-del-sueno-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-clinicas\/efectos-de-la-hipoxia-cronica-sostenida-e-intermitente-modelos-de-la-enfermedad-pulmonar-obstructiva-cronica-y-del-sa%c2%adndrome-de-apnea-del-sueno-humanos\/","title":{"rendered":"Efectos de la hipoxia cronica sostenida e intermitente. modelos de la enfermedad pulmonar obstructiva cr\u00f3nica y del s\u00edndrome de apnea del sue\u00f1o humanos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Del Carmen Gonzalez Martin <\/strong><\/h2>\n<p>La enfermedad pulmonar obstructiva cr\u00f3nica (epoc) y el s\u00edndrome de apnea obstructiva del sue\u00f1o (saos) humanos, son dos patolog\u00eda que se han constituido en la literatura m\u00e9dica como prototipos de enfermedades en las que la hipoxia que aparece es patol\u00f3gica. Mientras que en el epoc esta hipoxia cr\u00f3nica es sostenida en el saos es intermitente (se repite de forma c\u00edclica). En esta tesis doctoral se han pretendido crear dos modelos animales uno que intenta mimetizar la hipoxia cr\u00f3nica sostenida (10-11% o2, durante 8 y 15 d\u00edas de exposici\u00f3n) y otro la intermitente (30 episodios\/h, 8 h\/d\u00eda,  40s 10% o2 \/ 80 s 21% o2, 8 y 15 d\u00edas de exposici\u00f3n) para intentar esclarecer cual\/es de los s\u00edntomas caracter\u00edsticos de estas dos enfermedades est\u00e1n relacionados con la presencia en ellas de estos dos tipos de hipoxia cr\u00f3nica y cual es el papel, si lo hubiera, de las especies reactivas de ox\u00edgeno (ros) en esa sintomatolog\u00eda. Debemos de recordar que mientras que en el epoc hay un estado oxidativo franco, en la apnea del sue\u00f1o a\u00fan no est\u00e1 claro si esto es as\u00ed. Pretendemos establecer si la hubiera, una relaci\u00f3n entre ros y antioxidantes, para el abordaje de este objetivo llevamos a cabo de forma paralela un grupo de animales (tanto en hipoxia cr\u00f3nica sostenida como intermitente) a los cuales les administramos vitamina e (300 mg\/kg pellet) y \u00e1cido lipoico (1g\/ kg pellet) durante 8 y 15 d\u00edas de exposici\u00f3n, excepto en el grupo de intermitente que solamente se llev\u00f3 a cabo a los 15 d\u00edas. cuando valoramos el estado redox en pulm\u00f3n, h\u00edgado y cerebro tanto en la situaci\u00f3n sostenida como intermitente, podemos observar que la situaci\u00f3n sostenida, sobre todo a los 15 d\u00edas de exposici\u00f3n, esta acompa\u00f1ada por una disminuci\u00f3n del potencial redox del glutation (egsh), un aumento de la peroxidaci\u00f3n lip\u00eddica (lpo) y una alteraci\u00f3n en la actividad de varias enzimas involucradas en la eliminaci\u00f3n de ros, como son la glutation peroxidasa (gpx), catalasa (cat) y su<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de la hipoxia cronica sostenida e intermitente. modelos de la enfermedad pulmonar obstructiva cr\u00f3nica y del s\u00edndrome de apnea del sue\u00f1o humanos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de la hipoxia cronica sostenida e intermitente. modelos de la enfermedad pulmonar obstructiva cr\u00f3nica y del s\u00edndrome de apnea del sue\u00f1o humanos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Del Carmen Gonzalez Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Valladolid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/03\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Constancio Gonzalez Mart\u00ednez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: daniel Navajas navarro <\/li>\n<li> Guerrero montavez Juan  Miguel (vocal)<\/li>\n<li>Francisco Javier Casta\u00f1eda casado (vocal)<\/li>\n<li>Andr\u00e9s Esteban (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Del Carmen Gonzalez Martin La enfermedad pulmonar obstructiva cr\u00f3nica (epoc) y el s\u00edndrome de apnea obstructiva [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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