{"id":63608,"date":"2018-03-09T22:51:32","date_gmt":"2018-03-09T22:51:32","guid":{"rendered":""},"modified":"2018-03-09T22:51:32","modified_gmt":"2018-03-09T22:51:32","slug":"estudio-farmacocinetico-de-la-buprenorfina-tras-la-administracion-intravenosa-y-transdermica-en-la-especie-canina-determinacion-de-la-eficacia-analgesica-de-la-buprenorfina-administrada-subcutanea-y","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-agrarias\/estudio-farmacocinetico-de-la-buprenorfina-tras-la-administracion-intravenosa-y-transdermica-en-la-especie-canina-determinacion-de-la-eficacia-analgesica-de-la-buprenorfina-administrada-subcutanea-y\/","title":{"rendered":"Estudio farmacocin\u00e9tico de la buprenorfina tras la administraci\u00f3n intravenosa y transd\u00e9rmica en la especie canina. determinaci\u00f3n de la eficacia analg\u00e9sica de la buprenorfina administrada subcut\u00e1nea y transd\u00e9rmicamente en perras ovariohisterectomizadas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier Moll S\u00e1nchez <\/strong><\/h2>\n<p>La buprenorfina, opioide agonista parcial de los receptores mu, es un analg\u00e9sico habitulamente empleado en medicina veterinaria. Pocos estudios ha evaluado la farmacocin\u00e9tica y la farmacodinamia de la buprenorfina en sus diferentes presentaciones. En este estudio se pretende valorar, en primer lugar, la farmaconicin\u00e9tica de esta tras la administraci\u00f3n de un bolo intravenoso (fase 1); en segundo lugar, las concentraciones plasm\u00e1ticas tras su administraci\u00f3n transd\u00e9rmica durante 108 horas (fase 2);  y en tercer lugar, la eficacia analg\u00e9sica de la buprenorfina administrada subcut\u00e1nea y transd\u00e9rmicamente en perras sometidas a una ovariohisterectom\u00eda. En este estudio se muestra que la buprenorfina sigue una cin\u00e9tica tricompartimental, en donde la fase inicial se produce una r\u00e1pida distribuci\u00f3n hacia tejidos vascularizados, la fase segunda est\u00e1 mediada por los procesos de eliminaci\u00f3n del f\u00e1rmaco y la fase tercera puede reflejar la lenta asociaci\u00f3n\/disociaci\u00f3n de esta en sus receptores, pudiendo afectar a los efectos analg\u00e9sicos que presenta este f\u00e1rmaco. tras la administraci\u00f3n transd\u00e9rmica la buprenorfina aumenta progresivamente sus concentraciones plasm\u00e1ticas, hasta las 36-48 horas, manti\u00e9ndose en una fase estacionaria hasta un peridodo m\u00ednimo de 108 horas. Estas concentraciones son superiores a la cme descrita en medicina humana y son similares ha las obtenidas tras el bolo intravenoso, pudiendo indicar un posible efecto analg\u00e9sico de la administraci\u00f3n transd\u00e9rmica de buprenorfina. finalmente, la buprenorfina administrada subcut\u00e1nea y transd\u00e9rmicamente tiene una eficacia analg\u00e9sica similar en perras ovariohisterectomizadas. As\u00ed la buprenorfina administrada subcut\u00e1nea y transd\u00e9rmicamente durante el pre y postoperatorio mejora la recuperaci\u00f3n de los animales sometidos a una ovariohisterectom\u00eda.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio farmacocin\u00e9tico de la buprenorfina tras la administraci\u00f3n intravenosa y transd\u00e9rmica en la especie canina. determinaci\u00f3n de la eficacia analg\u00e9sica de la buprenorfina administrada subcut\u00e1nea y transd\u00e9rmicamente en perras ovariohisterectomizadas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio farmacocin\u00e9tico de la buprenorfina tras la administraci\u00f3n intravenosa y transd\u00e9rmica en la especie canina. determinaci\u00f3n de la eficacia analg\u00e9sica de la buprenorfina administrada subcut\u00e1nea y transd\u00e9rmicamente en perras ovariohisterectomizadas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier Moll S\u00e1nchez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/03\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Felix Garcia Arnas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: yvonne Espada gerlach <\/li>\n<li>Antonio Gonz\u00e1lez cantalapiedra (vocal)<\/li>\n<li>Francisco Laredo \u00e1lvarez (vocal)<\/li>\n<li>carles Crist\u00ed\u00b2fol adell (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier Moll S\u00e1nchez La buprenorfina, opioide agonista parcial de los receptores mu, es un analg\u00e9sico habitulamente empleado [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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