{"id":63654,"date":"2018-03-09T22:51:36","date_gmt":"2018-03-09T22:51:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/metabolismo-de-la-dopamina-degeneracion-neuronal-y-deterioro-mesoestriatal-asociado-al-envejecimiento\/"},"modified":"2018-03-09T22:51:36","modified_gmt":"2018-03-09T22:51:36","slug":"metabolismo-de-la-dopamina-degeneracion-neuronal-y-deterioro-mesoestriatal-asociado-al-envejecimiento","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/metabolismo-de-la-dopamina-degeneracion-neuronal-y-deterioro-mesoestriatal-asociado-al-envejecimiento\/","title":{"rendered":"Metabolismo de la dopamina, degeneraci\u00f3n neuronal y deterioro mesoestriatal asociado al envejecimiento"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ignacio De La Cruz Muros <\/strong><\/h2>\n<p>Los avances m\u00e9dicos han producido un incremento progresivo en la longevidad de la poblaci\u00f3n de los pa\u00edses desarrollados, y paralelamente un incremento de las enfermedades asociadas a la edad, entre ellas las enfermedades neurodegnerativas como la enfermedad de parkinson (ep). La ep afecta al 1% de la poblaci\u00f3n por encima de los 65 a\u00f1os y se caracteriza por la degeneraci\u00f3n de las neuronas dopamin\u00e9rgicas mesencef\u00e1licas y la ca\u00edda de los niveles de dopamina (da) en el estriado. El hecho de que la forma espor\u00e1dica de ep se presente a partir de la sexta-s\u00e9ptima d\u00e9cada de la vida ha sugerido una relaci\u00f3n entre envejecimiento cerebral y degeneraci\u00f3n dopamin\u00e9rgica, sin embargo existe controversia acerca de si el envejecimiento del sistema mesostriatal es un fen\u00f3meno degenerativo o bioqu\u00edmico, y tampoco sabemos cu\u00e1les son los mecanismos que determinan que las neuronas dopamin\u00e9rgicas envejecidas sean m\u00e1s vulnerables a la degeneraci\u00f3n. Los objetivos de este trabajo han sido estudiar: 1. La existencia de signos de degeneraci\u00f3n y alteraci\u00f3n en la ruta de s\u00edntesis de da en el sistema mesostriatal, atendiendo a posibles diferencias entre los compartimentos nigroestriatal y mesol\u00edmbico, y 2. Cambios en la expresi\u00f3n de los dos transportadores de da , dat (responsable de la recaptaci\u00f3n de da desde el espacio extracelular) y vmat2 ( responsable del almacenamiento vesicular de da protegi\u00e9ndola de la maquinaria metab\u00f3lica). El estudio se ha realizado en ratas de tres grupos de edad: j\u00f3venes (6 meses), de mediana edad (18-20 meses) y viejas (24-26 meses) utilizando t\u00e9cnicas morfol\u00f3gicas bioqu\u00edmicas y moleculares). nuestros hallazgos muestran que: 1. El sistema mesol\u00edmbico es m\u00e1s sensible a los  efectos del envejecimiento que el sistema nigroestriatal, con un mayor descenso de los niveles de dopamina (da) y  signos evidentes de degeneraci\u00f3n axonal. 2. Con respecto a la expresi\u00f3n de vmat2, no observamos cambios en los niveles totales de mensajero ni de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Metabolismo de la dopamina, degeneraci\u00f3n neuronal y deterioro mesoestriatal asociado al envejecimiento<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Metabolismo de la dopamina, degeneraci\u00f3n neuronal y deterioro mesoestriatal asociado al envejecimiento <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ignacio De La Cruz Muros <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 La laguna<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 28\/03\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Tom\u00e1s Gonz\u00e1lez Hern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Feria rodr\u00edguez <\/li>\n<li>Jos\u00e9 Luis Lanciego perez (vocal)<\/li>\n<li>Jos\u00e9 Luis Labandeira garcia (vocal)<\/li>\n<li>victor Garc\u00eda marin (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ignacio De La Cruz Muros Los avances m\u00e9dicos han producido un incremento progresivo en la longevidad de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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