{"id":63814,"date":"2008-04-04T00:00:00","date_gmt":"2008-04-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/study-the-regulation-and-signalling-of-cdk-2-cylin-o-complexes-during-apoptosis\/"},"modified":"2008-04-04T00:00:00","modified_gmt":"2008-04-04T00:00:00","slug":"study-the-regulation-and-signalling-of-cdk-2-cylin-o-complexes-during-apoptosis","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/bioquimica\/study-the-regulation-and-signalling-of-cdk-2-cylin-o-complexes-during-apoptosis\/","title":{"rendered":"Study the regulation and signalling of cdk-2-cylin o complexes during apoptosis"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ram\u00f3n Roset Huguet <\/strong><\/h2>\n<p>The aim of this thesis is the characterization of a protein involved in apoptosis. Our group has identified an early step common to different forms of intrinsic apoptosis stimuli. This step requires de novo synthesis of a novel cyclin, cyclin o, that upon apoptosis induction in lymphoid cells forms active complexes, primarily with cdk2. Cyclin o expression precedes glucocorticoid and gamma radiation-induced apoptosis in vivo in mouse thymus. Knocking down the endogenous expression of cyclin o by shrna leads to the inhibition of glucocorticoid and dna damage-induced apoptosis while leaving cd95 death receptor mediated apoptosis intact. This data demonstrates that apoptosis induction in lymphoid cells is one of the physiological roles of cyclin o and it does not act by perturbing a normal cellular process such as the cell cycle. In addition we have identified c-myb a substrate of cdk2-cyclin o complexes and we show that c-myb is downregulated during apoptosis of lymphoid cells.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Study the regulation and signalling of cdk-2-cylin o complexes during apoptosis<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Study the regulation and signalling of cdk-2-cylin o complexes during apoptosis <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ram\u00f3n Roset Huguet <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/04\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gabriel Gil G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Garcia de herreros madue\u00f1o <\/li>\n<li>carme Caelles franch (vocal)<\/li>\n<li>joan Seoane suarez (vocal)<\/li>\n<li>ra\u00fal M\u00e9ndez de la iglesia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ram\u00f3n Roset Huguet The aim of this thesis is the characterization of a protein involved in apoptosis. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,36483,160,18712],"tags":[20204,54147,53674,63383,140883,15068],"class_list":["post-63814","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-biologia-molecular","category-bioquimica","category-pompeu-fabra","tag-antonio-garcia-de-herreros-madueno","tag-carme-caelles-franch","tag-gabriel-gil-gomez","tag-joan-seoane-suarez","tag-ramon-roset-huguet","tag-raul-mendez-de-la-iglesia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/63814","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=63814"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/63814\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=63814"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=63814"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=63814"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}