{"id":63831,"date":"2008-07-04T00:00:00","date_gmt":"2008-07-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-de-virulencia-y-patogenesis-de-vibrio-vulnificus-biotipo-2-serovar-e\/"},"modified":"2008-07-04T00:00:00","modified_gmt":"2008-07-04T00:00:00","slug":"factores-de-virulencia-y-patogenesis-de-vibrio-vulnificus-biotipo-2-serovar-e","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/factores-de-virulencia-y-patogenesis-de-vibrio-vulnificus-biotipo-2-serovar-e\/","title":{"rendered":"\u00abfactores de virulencia y patog\u00e9nesis de vibrio vulnificus biotipo 2 serovar e\u00bb"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esmeralda Valiente Conejero <\/strong><\/h2>\n<p>Vibrio vulnificus biotipo 2 comprende las cepas de vibrio vulnificus capaces de causar vibriosis en peces. En los \u00faltimos a\u00f1os, se !1an realizado avances importantes en el conocimiento de la biolog\u00eda de este pat\u00f3geno, sin embargo, no se han estudiado los factores de virulencia importantes en la patog\u00e9nesis de la vibriosis producida por esta bacteria. En la presente tesis doctoral hemos estudiado el papel del pl\u00e1smido pr99, recientemente descrito, y el de factores de virulencia seleccionados, la c\u00e1psula, el lps y la metaloproteasa vvp en la patog\u00e9nesis de la vibriosis causada por este pat\u00f3geno. Para ello se ha obtenido una cepa deficiente en el pl\u00e1smido pr99, as\u00ed como cepas deficientes en cada uno de los factores y se han comparado con la cepa parental en ensayos de virulencia as\u00ed como de colonizaci\u00f3n y de resistencia a las defensas innatas de la anguila. hemos demostrado que la metaloproteasa en v. Vulnificus biotipo 2 es un factor de colonizaci\u00f3n que media quimiotaxis haciael moco que recubre la agalla, probablemente al unirse a mucina y degradarla. Los estudios histopatol\u00f3gicos realizados con elmutante en metaloproteasa nos indican que esta prote\u00edna no tiene ning\u00fan papel en la producci\u00f3n de hemorragias. El ant\u00edgeno-o tiene un papel en el establecimiento de agrupaciones bacterianas en la superficie de las agallas que, al estar recubiertas de moco, resistir\u00e1n mejor las condiciones adversas. En contraposici\u00f3n, la c\u00e1psula no tiene un papel tan claro en la colonizaci\u00f3n de la superficie externa. Ambas estructuras de naturaleza polisacar\u00eddica son muy importantes en el proceso de colonizaci\u00f3n del medio interno.  Con respecto al pl\u00e1smido, \u00e9ste codifica para un sistema de resistencia a los mecanismos de inmunidad innata que es espec\u00edfico de hospedador. Tambi\u00e9n, hemos demostrado que vibrio vulnificus produce autoinductores del tipo acil-homoserinas lactonas (ahl) implicados en el sistema de quorum sensing. Estos compuestos se producen cuando se<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abfactores de virulencia y patog\u00e9nesis de vibrio vulnificus biotipo 2 serovar e\u00bb<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abfactores de virulencia y patog\u00e9nesis de vibrio vulnificus biotipo 2 serovar e\u00bb <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esmeralda Valiente Conejero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/04\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Amaro Gonz\u00e1lez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alicia Estevez toranzo <\/li>\n<li>Jos\u00e9 Meseguer pe\u00f1alver (vocal)<\/li>\n<li>Mar\u00eda  Jos\u00e9 Figueras salvat (vocal)<\/li>\n<li>lLuis Tort bardolet (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esmeralda Valiente Conejero Vibrio vulnificus biotipo 2 comprende las cepas de vibrio vulnificus capaces de causar vibriosis [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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