{"id":63873,"date":"2008-09-04T00:00:00","date_gmt":"2008-09-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-regulacion-de-la-senal-de-calcio-por-aciletanolamidas-y-derivados-en-islotes-de-langerhans-de-raton\/"},"modified":"2008-09-04T00:00:00","modified_gmt":"2008-09-04T00:00:00","slug":"estudio-de-la-regulacion-de-la-senal-de-calcio-por-aciletanolamidas-y-derivados-en-islotes-de-langerhans-de-raton","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/metabolismo-energetico\/estudio-de-la-regulacion-de-la-senal-de-calcio-por-aciletanolamidas-y-derivados-en-islotes-de-langerhans-de-raton\/","title":{"rendered":"Estudio de la regulacion de la se\u00f1al de calcio por aciletanolamidas y derivados en islotes de langerhans de raton"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pablo Juan  Pico <\/strong><\/h2>\n<p>Las aciletanolamidas son mol\u00e9culas de producci\u00f3n end\u00f3gena capaces de alterar procesos metab\u00f3licos,  como por ejemplo,   la sensaci\u00f3n de apetito.   \u00e9stas act\u00faan a trav\u00e9s de los receptores de cannabionoides  (cb) o bien sobre los receptores activados por proliferadores peroxisomales de tipo alfa (pparalfa).  En esta tesis se ha estudiado el efecto de las aciletanolamidas y otros compuestos an\u00e1logos sint\u00e9ticos sobre las diferentes poblaciones celulares de los islotes de langerhans  (alfa,   beta y delta),  unidad funcional del p\u00e1ncreas endocrino.  El estudio se ha centrado en el efecto sobre las oscilaciones de calcio intracelular,  cati\u00f3n que en \u00faltima instancia es responsable de la secreci\u00f3n hormonal en los islotes.  El receptor cb1 se expresa mayoritariamente en c\u00e9lula alfa,  mientras que cb2 se expresa de forma similar en los tres tipos celulares. Ambos receptores disminuyen la secreci\u00f3n de insulina en la c\u00e9lula beta pancre\u00e1tica a trav\u00e9s de la inhibici\u00f3n de las oscilaciones de calcio.  En c\u00e9lula alfa el receptor cb1 provoca un efecto dual aumentando o disminuyendo la frecuencia de las oscilaciones de calcio,  mientras que el cb2 solo disminuye la frecuencia.  En c\u00e9lulas delta,  solo el receptor cb2 altera la se\u00f1al de calcio, aumentando la concentraci\u00f3n de calcio intracelular,  sin observar ning\u00fan efecto tras la estimulaci\u00f3n de los receptores cb1.  En el caso del receptor nuclear pparalfa,  este se encuentra distribuido en citosol,  n\u00facleo y membrana plasm\u00e1tica de las c\u00e9lulas beta.  Los ligandos de este receptor provocan un efecto r\u00e1pido disminuyendo la concentraci\u00f3n de calcio intracelular mediante un mecanismo no gen\u00f3mico,  inhibiendo por tanto,  la secreci\u00f3n de insulina.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la regulacion de la se\u00f1al de calcio por aciletanolamidas y derivados en islotes de langerhans de raton<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la regulacion de la se\u00f1al de calcio por aciletanolamidas y derivados en islotes de langerhans de raton <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pablo Juan  Pico <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/04\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Angel Nadal Navajas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fernando Rodriguez de fonseca <\/li>\n<li>Juan  enrique Martinez pinna lopez (vocal)<\/li>\n<li>cristina Ripoll orts (vocal)<\/li>\n<li>Francisco Javier Bermudez  silva (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pablo Juan Pico Las aciletanolamidas son mol\u00e9culas de producci\u00f3n end\u00f3gena capaces de alterar procesos metab\u00f3licos, como por [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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