{"id":63874,"date":"2008-10-04T00:00:00","date_gmt":"2008-10-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-efecto-carda%c2%adaco-de-un-nuevo-donador-de-oxido-na%c2%adtrico-en-un-modelo-experimental-de-cardiopata%c2%ada-hipertensiva\/"},"modified":"2008-10-04T00:00:00","modified_gmt":"2008-10-04T00:00:00","slug":"estudio-del-efecto-carda%c2%adaco-de-un-nuevo-donador-de-oxido-na%c2%adtrico-en-un-modelo-experimental-de-cardiopata%c2%ada-hipertensiva","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-efecto-carda%c2%adaco-de-un-nuevo-donador-de-oxido-na%c2%adtrico-en-un-modelo-experimental-de-cardiopata%c2%ada-hipertensiva\/","title":{"rendered":"Estudio del efecto card\u00edaco de un nuevo donador de \u00f3xido n\u00edtrico en un modelo experimental de cardiopat\u00edahipertensiva."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gema Ruiz Hurtado <\/strong><\/h2>\n<p>En los desordenes cardiovasculares como la hipertrofia y la insuficiencia card\u00edaca existe una producci\u00f3n reducida de \u00f3xido n\u00edtrico (no) en el coraz\u00f3n. La terapia con nitratos convencionales est\u00e1 limitada por la aparici\u00f3n de efectos adversos como los episodios hipotensivos y el desarrollo de tolerancia a largo plazo. El nuevo donador de no, denominado la-419, ha demostrado poseer propiedades anti-tromb\u00f3ticas y anti-isqu\u00e9micas importantes sin desarrollar tales efectos. El objetivo de la presente tesis doctoral fue analizar el efecto del tratamiento cr\u00f3nico con el nuevo donador de no, la-419, sobre el remodelado card\u00edaco asociado al desarrollo de hipertrofia card\u00edaca. La hipertrofia ventricular izquierda (hvi) fue inducida por estenosis a\u00f3rtica en ratas macho sprague-dawley. El tratamiento con la-419 (30 mg\/kg\/d\u00eda) comenz\u00f3 una vez que la hvi estaba establecida. El an\u00e1lisis de diferentes par\u00e1metros morfom\u00e9tricos (como el peso del coraz\u00f3n, el cociente peso coraz\u00f3n\/corporal y el di\u00e1metro del vi) determin\u00f3 el grado de desarrollo de hipertrofia card\u00edaca y el an\u00e1lisis histol\u00f3gico nos revel\u00f3 la presencia de fibrosis intersticial y perivascular. La presi\u00f3n arterial fue determinada a trav\u00e9s de la canulaci\u00f3n de la car\u00f3tida izquierda. El nivel de expresi\u00f3n de la principal enzima encargada de sintetizar el no en el coraz\u00f3n (la \u00f3xido n\u00edtrico sintasa endotelial o enos) y de sus reguladores alost\u00e9ricos, la chaperona hsp90 y caveolina-3, se determinaron mediante la t\u00e9cnica de western blot. El contenido en cgmp fue  analizado por enzimoinmunoensayo. Los resultados m\u00e1s significativos obtenidos en este trabajo de investigaci\u00f3n fueron que el tratamiento con la-419 era capaz de disminuir todos los par\u00e1metros utilizados para definir la presencia de hvi, as\u00ed como de prevenir la aparici\u00f3n de la fibrosis que mostraban los animales hipertr\u00f3ficos. Todos estos cambios fueron observados sin modificaci\u00f3n alguna de la hipertensi\u00f3n arterial que los animales<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del efecto card\u00edaco de un nuevo donador de \u00f3xido n\u00edtrico en un modelo experimental de cardiopat\u00edahipertensiva.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del efecto card\u00edaco de un nuevo donador de \u00f3xido n\u00edtrico en un modelo experimental de cardiopat\u00edahipertensiva. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gema Ruiz Hurtado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/04\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Carmen Delgado Canencia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Pedro Lorenzo Fern\u00e1ndez <\/li>\n<li>\u00f3scar Casis S\u00e1enz (vocal)<\/li>\n<li> Fortu\u00f1o Cebamanos M\u00aa Antonia (vocal)<\/li>\n<li>Jes\u00fas Hern\u00e1ndez Cascales (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gema Ruiz Hurtado En los desordenes cardiovasculares como la hipertrofia y la insuficiencia card\u00edaca existe una producci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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