{"id":63893,"date":"2008-11-04T00:00:00","date_gmt":"2008-11-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-cla%c2%adnico-patologico-y-biologa%c2%ada-molecular-del-dermatofibrosarcoma\/"},"modified":"2008-11-04T00:00:00","modified_gmt":"2008-11-04T00:00:00","slug":"estudio-cla%c2%adnico-patologico-y-biologa%c2%ada-molecular-del-dermatofibrosarcoma","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/histopatologia\/estudio-cla%c2%adnico-patologico-y-biologa%c2%ada-molecular-del-dermatofibrosarcoma\/","title":{"rendered":"Estudio cl\u00ednico-patol\u00f3gico y biolog\u00eda molecular del dermatofibrosarcoma"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Beatriz Llombart Cussac <\/strong><\/h2>\n<p>Estudio cl\u00ednico-patol\u00f3gico y biolog\u00eda molecular del dermatofibrosaroma. antecedentes del tema: el dermatofibrosarcoma protuberans (dfsp) es un tumor poco frecuente, de malignidad intermedia, ya que presenta una gran agresividad local, con tendencia a la recidiva local, pero poca capacidad de producir met\u00e1stasis a distancia (1-4%). La histolog\u00eda del dfsp es la de un tumor d\u00e9rmico, mal delimitado compuesto por una densa proliferaci\u00f3n de c\u00e9lulas fusiformes, monomorfas, con escaso pleomorfismo y una baja actividad mit\u00f3sica. El diagn\u00f3stico, en ocasiones, puede resultar dif\u00edcil, teniendo que recurrir a t\u00e9cnicas complementarias como la inmunohistoqu\u00edmica o la biolog\u00eda molecular. Aproximadamente entre el 80-90% de los dfsp expresan cd34, siendo actualmente el principal marcador utilizado para el diagn\u00f3stico diferencial con otros tumores. A nivel citogen\u00e9tico, el dfsp se caracteriza por presentar una translocaci\u00f3n rec\u00edproca t(17;22)(q22;q13) o, m\u00e1s a menudo, cromosomas supernumerarios en anillo derivados de la t(17;22)15. Como consecuencia de esta translocaci\u00f3n, se produce una fusi\u00f3n g\u00e9nica entre el gen del col\u00e1geno tipo i ? (Col1a1), en el cromosoma 17q, con el gen de la cadena \u00edY del factor de crecimiento derivado de las plaquetas  (pdgfb), en  el cromosoma 22q. Sin embargo, los estudios moleculares realizados hasta la fecha son de casos aislados o series cortas, desconoci\u00e9ndose la incidencia real de dicha alteraci\u00f3n. En todos los casos descritos hasta la fecha el punto de fusi\u00f3n del pdgfb es constaste (ex\u00f3n 2), sin embargo, en el col1a1 cualquiera de los exones de la regi\u00f3n alfa helicoidal (exones 6-49) pueden estar implicados. La implicaci\u00f3n cl\u00ednica y biol\u00f3gica de esta heterogenicidad en el punto de fusi\u00f3n del col1a1 est\u00e1 todav\u00eda por establecer. Por otra parte, la determinaci\u00f3n de los mecanismos moleculares implicados en la g\u00e9nesis de este sarcoma proporciona no s\u00f3lo nuevas claves diagn\u00f3sticas, sino tambi\u00e9n terap\u00e9uticas, atendiend<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio cl\u00ednico-patol\u00f3gico y biolog\u00eda molecular del dermatofibrosarcoma<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio cl\u00ednico-patol\u00f3gico y biolog\u00eda molecular del dermatofibrosarcoma <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Beatriz Llombart Cussac <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/04\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Llombart Bosch<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Pell\u00edn p\u00e9rez <\/li>\n<li>Luis Requena caballero (vocal)<\/li>\n<li>felix Contreras rubio (vocal)<\/li>\n<li>samuel Navarro fos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Beatriz Llombart Cussac Estudio cl\u00ednico-patol\u00f3gico y biolog\u00eda molecular del dermatofibrosaroma. antecedentes del tema: el dermatofibrosarcoma protuberans (dfsp) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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