{"id":63903,"date":"2008-11-04T00:00:00","date_gmt":"2008-11-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/reacciones-de-carbolitiacion-y-heck-intramoleculares-sintesis-de-pirrolo12-bisoquinolinas-y-pirrolo21-aisoindoles\/"},"modified":"2008-11-04T00:00:00","modified_gmt":"2008-11-04T00:00:00","slug":"reacciones-de-carbolitiacion-y-heck-intramoleculares-sintesis-de-pirrolo12-bisoquinolinas-y-pirrolo21-aisoindoles","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/compuestos-heterociclicos\/reacciones-de-carbolitiacion-y-heck-intramoleculares-sintesis-de-pirrolo12-bisoquinolinas-y-pirrolo21-aisoindoles\/","title":{"rendered":"Reacciones de carbolitiacion y heck intramoleculares. sintesis de pirrolo[1,2-b]isoquinolinas y pirrolo[2,1-a]isoindoles"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Sergio Lage Medina <\/strong><\/h2>\n<p>En el trabajo de investigaci\u00f3n que se recoge en la presente memoria se ha efectuado un estudio comparativo de las reacciones de carbolitiaci\u00f3n y heck intramoleculares sobre n-(2-yodobencil) pirroles 2-alquenilsustituidos, dirigidas a la s\u00edntesis de pirrolo [1,2-b] isoquinolinas.  por una parte, se han investigado las reacciones de carbolitiaci\u00f3n intramolecular, evaluando el comportamiento de diferentes electr\u00f3filos internos como sustituyentes de la olefina, demostrando que es necesaria la presencia de grupos atractores de electrones para que tenga lugar la ciclaci\u00f3n.  por otro lado, la reacci\u00f3n de heck intramolecular ha permitido sintetizar de modo quimioselectivo pirrolo [2,1-a] isoindoles y pirrolo [1,2-b] isoquinolinas, independientemente de la sustituci\u00f3n presente en la olefina, variando tan s\u00f3lo el sistema catal\u00edtico de paladio empleado en la reacci\u00f3n.  finalmente, como aplicaci\u00f3n de ambas metodolog\u00edas sint\u00e9ticas se estudi\u00f3 la posibilidad de acceder al esqueleto de licorano, el cual presentaba una estructura de indolizina fusionada. Sin embargo, ninguna de las variaciones efectuadas sobre el sustrato de partida condujo con \u00e9xito a la s\u00edntesis del esqueleto del licorano.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Reacciones de carbolitiacion y heck intramoleculares. sintesis de pirrolo[1,2-b]isoquinolinas y pirrolo[2,1-a]isoindoles<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Reacciones de carbolitiacion y heck intramoleculares. sintesis de pirrolo[1,2-b]isoquinolinas y pirrolo[2,1-a]isoindoles <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Sergio Lage Medina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/04\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Esther Lete Exposito<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Molina buend\u00eda <\/li>\n<li>pedro Merino filella (vocal)<\/li>\n<li>carmen N\u00e1jera domingo (vocal)<\/li>\n<li>adelina Vallribera mass\u00f3 (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sergio Lage Medina En el trabajo de investigaci\u00f3n que se recoge en la presente memoria se ha [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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