{"id":6391,"date":"1995-01-01T00:00:00","date_gmt":"1995-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1995\/01\/01\/variabilidad-del-vih-1-implicaciones-en-la-aparicion-de-variantes-con-susceptibilidad-reducida-a-inhibidores-de-la-retrotranscriptasa\/"},"modified":"1995-01-01T00:00:00","modified_gmt":"1995-01-01T00:00:00","slug":"variabilidad-del-vih-1-implicaciones-en-la-aparicion-de-variantes-con-susceptibilidad-reducida-a-inhibidores-de-la-retrotranscriptasa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/variabilidad-del-vih-1-implicaciones-en-la-aparicion-de-variantes-con-susceptibilidad-reducida-a-inhibidores-de-la-retrotranscriptasa\/","title":{"rendered":"Variabilidad del vih-1. implicaciones en la aparicion de variantes con susceptibilidad reducida a inhibidores de la retrotranscriptasa."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Najera Vazquez De Parga Isabel <\/strong><\/h2>\n<p>Para el tratamiento de la infeccion por el virus de la inmunodeficiencia humana tipo-1 (vih-1) se emplean fundamentalmente inhibidores de la retrotranscriptasa virica. En todos los casos se han detectado virus variantes con susceptibilidad reducida a las drogas tras el tratamiento. Este cambio fenotipico se ha relacionado con sustituciones de aminoacidos en la enzima. En este trabajo se describe la deteccion de virus variantes resistentes a drogas procedentes de pacientes que no habian recibido tratamiento antirretrovirico. Una explicacion a este fenomeno es la enorme variabilidad genetica que presenta el vih, que tiene su origen en la tasa de error de la retrotranscriptasa. Como consecuencia las poblaciones viricas con genoma rna presentan una estructura de cuasiespecies que permite la presencia de virus variantes con distintas caracteristicas genotipicas y fenotipicas susceptibles de seleccion ante cambios de las condiciones ambientales. En esta tesis se pone de manifiesto la relevancia de este hecho en relacion con la deteccion de virus resistentes a drogas antes de recibir tratamiento.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Variabilidad del vih-1. implicaciones en la aparicion de variantes con susceptibilidad reducida a inhibidores de la retrotranscriptasa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Variabilidad del vih-1. implicaciones en la aparicion de variantes con susceptibilidad reducida a inhibidores de la retrotranscriptasa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Najera Vazquez De Parga Isabel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1995<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Cecilio L\u00f3pez Gal\u00edndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Montero Carnerero <\/li>\n<li>Mar\u00eda no Esteban Rodriguez (vocal)<\/li>\n<li>Luis Carrasco Llamas (vocal)<\/li>\n<li>Rafael Mu\u00f1oz Fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Najera Vazquez De Parga Isabel Para el tratamiento de la infeccion por el virus de la inmunodeficiencia [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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