{"id":63953,"date":"2018-03-09T22:51:57","date_gmt":"2018-03-09T22:51:57","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-y-sintesis-de-una-nueva-clase-de-analogos-de-la-vitamina-d3-con-anillo-d-bencenico\/"},"modified":"2018-03-09T22:51:57","modified_gmt":"2018-03-09T22:51:57","slug":"diseno-y-sintesis-de-una-nueva-clase-de-analogos-de-la-vitamina-d3-con-anillo-d-bencenico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/santiago-de-compostela\/diseno-y-sintesis-de-una-nueva-clase-de-analogos-de-la-vitamina-d3-con-anillo-d-bencenico\/","title":{"rendered":"Dise\u00f1o y sintesis de una nueva clase de analogos de la vitamina d3 con anillo d bencenico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Silvina Laura Eduardo Canosa <\/strong><\/h2>\n<p>En base a la estructura cristalogr\u00e1fica del complejo lignado-receptor y c\u00e1lculos de docking se dise\u00f1a una nueva clase de an\u00e1logos de la vitamina d con una unidad benc\u00e9nica que sustituye al anillo d del lignado natural. Se realiza un gran esfuerzo sint\u00e9tico para desarrollar una estrategia general de s\u00edntesis de esta nueva clase de compuestos de potencial inter\u00e9s terap\u00e9utico. Como hechos mas relevantes es de destacar: (1) la influencia que un anillo arom\u00e1tico ejerce sobre el desplazamiento sigmatr\u00f3pico. [1.7]-h en trieos tipo vitamina d y su modulaci\u00f3n v\u00eda complejos de cr sobre la unidad arom\u00e1tica, que es de inter\u00e9s en s\u00edntesis en general. (2) el desarrollo de un proceso tipo domino catalizado por pd(0) que incluye la carbociclaci\u00f3n de un enoltriflato en\u00ednico seguido de acoplamiento del intermedio de pd(ii) resultante con organomet\u00e1licos de zinc y boro. Este proceso abre nuevos caminos par ala s\u00edntesis del sistema tri\u00e9nico de an\u00e1logos de la vitamina d desconocidos y dif\u00edciles de preparar por las rutas de s\u00edntesis existentes.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o y sintesis de una nueva clase de analogos de la vitamina d3 con anillo d bencenico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o y sintesis de una nueva clase de analogos de la vitamina d3 con anillo d bencenico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Silvina Laura Eduardo Canosa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 14\/04\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Mouri\u00f1o Mosquera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 joaquin Barluenga mur <\/li>\n<li>julio cesar Podesta (vocal)<\/li>\n<li>Jos\u00e9 da Silva cavaleiro (vocal)<\/li>\n<li>santos Fustero lardi\u00e9s (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Silvina Laura Eduardo Canosa En base a la estructura cristalogr\u00e1fica del complejo lignado-receptor y c\u00e1lculos de docking [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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