{"id":64020,"date":"2018-03-09T22:52:00","date_gmt":"2018-03-09T22:52:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-la-endoglina-en-la-proliferacion-celular-y-acumulacion-de-matriz-extracelular\/"},"modified":"2018-03-09T22:52:00","modified_gmt":"2018-03-09T22:52:00","slug":"papel-de-la-endoglina-en-la-proliferacion-celular-y-acumulacion-de-matriz-extracelular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/genetica-bioquimica\/papel-de-la-endoglina-en-la-proliferacion-celular-y-acumulacion-de-matriz-extracelular\/","title":{"rendered":"Papel de la endoglina en la proliferaci\u00f3n celular y acumulaci\u00f3n de matriz extracelular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Patricia Alvarez Mu\u00f1oz <\/strong><\/h2>\n<p>En este trabajo se estudia la implicaci\u00f3n de endoglina (eng), receptor no se\u00f1alizante de tgf-\u00edY1, en la acumulaci\u00f3n de matriz extracelular (mec) y la proliferaci\u00f3n celular en un modelo de c\u00e9lulas mesangiales humanas inmortalizadas (k-18) y c\u00e9lulas mesangiales de ratas wistar-kyoto (wky) en cultivo primario,  en presencia o ausencia de tgf-\u00edY1. Para ello se sobreexpres\u00f3 eng humana en las c\u00e9lulas k-18 y c\u00e9lulas wky, y se disminuy\u00f3 su expresi\u00f3n en las c\u00e9lulas k-18.  la sobreexpresi\u00f3n de eng en las c\u00e9lulas k-18 indujo un aumento de la acumulaci\u00f3n de col\u00e1geno-i y fibronectina y menor respuesta a tgf-b1 respecto a sus controles. En las c\u00e9lulas wky, la sobreexpresi\u00f3n de eng indujo una mayor expresi\u00f3n y acumulaci\u00f3n de col\u00e1geno-i y fibronectina respecto a sus controles, sin observarse cambios tras el tratamiento con tgf-\u00edY1 en ambos grupos de c\u00e9lulas. el silenciamiento de eng en las c\u00e9lulas k-18 modific\u00f3 la s\u00edntesis de mec aunque el tratamiento con tgf-\u00edY1 indujo mayor respuesta en la acumulaci\u00f3n de fibronectina. la sobreexpresi\u00f3n de eng en las c\u00e9lulas wky indujo una menor proliferaci\u00f3n en estas c\u00e9lulas respecto a sus controles, sin ser estad\u00edsticamente significativa. La sobreexpresi\u00f3n de endoglina en c\u00e9lulas k-18 crecidas sin suero disminuy\u00f3 la expresi\u00f3n de pcna, ciclina b1 y cdc25b mientras que la presencia de suero disminuy\u00f3 la expresi\u00f3n de ciclina e y a.  en ausencia de suero el silenciamiento de eng indujo un aumento en la s\u00edntesis de cdc25b, mientras que en presencia de suero disminuy\u00f3 la s\u00edntesis de cdc25b, ciclina e y b1, pudiendo indicar una disminuci\u00f3n de la proliferaci\u00f3n en estas condiciones. de estos resultados concluimos que la distinta expresi\u00f3n de eng en las c\u00e9lulas mesangiales modifica la s\u00edntesis de prote\u00ednas del ciclo celular y la s\u00edntesis y acumulaci\u00f3n de mec, y esta modificaci\u00f3n depende de la presencia o no de suero en el medio de cultivo. Adem\u00e1s, tgf-b1 no siempre modula la s\u00edntesis de mec tras los cambios en la expresi\u00f3n de eng.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de la endoglina en la proliferaci\u00f3n celular y acumulaci\u00f3n de matriz extracelular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de la endoglina en la proliferaci\u00f3n celular y acumulaci\u00f3n de matriz extracelular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Patricia Alvarez Mu\u00f1oz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/04\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Miguel Lopez Novoa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda abdona L\u00f3pez rodr\u00edguez <\/li>\n<li>angel Sanchez rodriguez (vocal)<\/li>\n<li>Alberto Mart\u00ednez castelao (vocal)<\/li>\n<li>mercedes Zubiaur marcos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Patricia Alvarez Mu\u00f1oz En este trabajo se estudia la implicaci\u00f3n de endoglina (eng), receptor no se\u00f1alizante de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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