{"id":64024,"date":"2018-03-09T22:52:00","date_gmt":"2018-03-09T22:52:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-la-expresion-genica-en-tejido-adiposo-visceral-de-ninos-obesos-en-edad-prepuberal\/"},"modified":"2018-03-09T22:52:00","modified_gmt":"2018-03-09T22:52:00","slug":"analisis-de-la-expresion-genica-en-tejido-adiposo-visceral-de-ninos-obesos-en-edad-prepuberal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/endocrinologia\/analisis-de-la-expresion-genica-en-tejido-adiposo-visceral-de-ninos-obesos-en-edad-prepuberal\/","title":{"rendered":"An\u00e1lisis de la expresi\u00f3n g\u00e9nica en tejido adiposo visceral de ni\u00f1os obesos en edad prepuberal"},"content":{"rendered":"

Tesis doctoral de Ines Mar\u00eda Tofe Valera <\/strong><\/h2>\n

La obesidad infantil constituye la enfermedad nutricional m\u00e1s frecuente en el mundo desarrollado. Como resultado de esta epidemia, est\u00e1n apareciendo en la infancia y en la adolescencia una serie de factores de riesgo y enfermedades cr\u00f3nicas. El s\u00edndrome metab\u00f3lico, que se caracteriza fundamentalmente por presentar hipertensi\u00f3n arterial, dislipemia, hiperinsulinemia y resistencia a la insulina puede estar presente ya en la infancia. La etiolog\u00eda de la obesidad es desconocida aunque se sabe que existen alteraciones endocrinol\u00f3gicas y metab\u00f3licas. En su aparici\u00f3n contribuyen e interaccionan factores gen\u00e9ticos a\u00fan no bien determinados, as\u00ed como factores ambientales que se interrelacionan entre s\u00ed. el objetivo general del trabajo ha sido evaluar la expresi\u00f3n g\u00e9nica diferencial de tejido adiposo intraabdominal de ni\u00f1os obesos en edad prepuberal frente a ni\u00f1os no obesos. Del mismo modo, se ha pretendido conocer la proporci\u00f3n de genes afectados agrupados seg\u00fan el proceso biol\u00f3gico, componente celular y funci\u00f3n molecular. En esta l\u00ednea se ha estudiado la expresi\u00f3n de aquellos genes que intervienen en la cascada de se\u00f1alizaci\u00f3n de insulina, metabolismo lip\u00eddico y mecanismos inflamatorios, estableciendo un nexo de uni\u00f3n entre s\u00ed y una posible asociaci\u00f3n con el desaarrollo de resistencia a la acci\u00f3n insul\u00ednica. se seleccionaron 20 ni\u00f1os obesos y 20 ni\u00f1os nomopeso que constituyeron el grupo control, en estado prepuberal y a los que se iba a realizar una laparatom\u00eda diagn\u00f3stica\/terap\u00e9utica por dolor abdominal, inicialmente se estudiaron por microarray y de dna 5 ni\u00f1os obesos y 6 controles y se encontraron, con una p<0,001, 57 secuencias g\u00e9nicas expresadas diferencialmente en obesos frente a no obesos en sentido de sobreexpresi\u00f3n o represi\u00f3n. estos resultados indican que ya a edades precoces se producen cambios en la expresi\u00f3n g\u00e9nica en tejido adiposo visceral que a su vez es el m\u00e1s resistente a la acci\u00f3n de la insulina.\n\n\n\n \n\n\n

Datos acad\u00e9micos de la tesis doctoral \u00abAn\u00e1lisis de la expresi\u00f3n g\u00e9nica en tejido adiposo visceral de ni\u00f1os obesos en edad prepuberal<\/strong>\u00ab<\/h3>\n
    \n
  • T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de la expresi\u00f3n g\u00e9nica en tejido adiposo visceral de ni\u00f1os obesos en edad prepuberal <\/li>\n
  • Autor:<\/strong>\u00a0 Ines Mar\u00eda Tofe Valera <\/li>\n
  • Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n
  • Fecha de lectura de la tesis:<\/strong>\u00a0 17\/04\/2008<\/li>\n<\/ul>\n

     <\/p>\n

    Direcci\u00f3n y tribunal<\/h3>\n
      \n
    • Director de la tesis<\/strong>\n
        \n
      • Ram\u00f3n Ca\u00f1ete Estrada<\/li>\n<\/ul>\n<\/li>\n
      • Tribunal<\/strong>\n
          \n
        • Presidente del tribunal: Luis Jimenez reina <\/li>\n
        • Rafael Tojo sierra (vocal)<\/li>\n
        • m. mercedes Gil campos (vocal)<\/li>\n
        • Jos\u00e9 Antonio Gomez capilla (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n

           <\/p>\n","protected":false},"excerpt":{"rendered":"

          Tesis doctoral de Ines Mar\u00eda Tofe Valera La obesidad infantil constituye la enfermedad nutricional m\u00e1s frecuente en el mundo desarrollado. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[973,851,2135,2008],"tags":[141316,3668,8003,83034,2517,2403],"class_list":["post-64024","post","type-post","status-publish","format-standard","hentry","category-cordoba","category-endocrinologia","category-fisiologia-endocrina","category-morfologia-celular","tag-ines-maria-tofe-valera","tag-jose-antonio-gomez-capilla","tag-luis-jimenez-reina","tag-m-mercedes-gil-campos","tag-rafael-tojo-sierra","tag-ramon-canete-estrada"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/64024","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=64024"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/64024\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=64024"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=64024"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=64024"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}