{"id":64057,"date":"2018-03-09T22:52:04","date_gmt":"2018-03-09T22:52:04","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-biofarmaceutico-y-paraistologico-de-una-formulacion-de-albendazol-en-hidroxipropil-beta-ciclodextrina\/"},"modified":"2018-03-09T22:52:04","modified_gmt":"2018-03-09T22:52:04","slug":"estudio-biofarmaceutico-y-paraistologico-de-una-formulacion-de-albendazol-en-hidroxipropil-beta-ciclodextrina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-biofarmaceutico-y-paraistologico-de-una-formulacion-de-albendazol-en-hidroxipropil-beta-ciclodextrina\/","title":{"rendered":"Estudio biofarmac\u00e9utico y paraistol\u00f3gico de una formulaci\u00f3n de albendazol en hidroxipropil-beta-ciclodextrina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Jos\u00e9 Garc\u00eda Rodr\u00edguez <\/strong><\/h2>\n<p>El abendazol es un antihelm\u00edntico de amplio espectro utilizado en el tratamiento de numerosas infecciones producidas por par\u00e1sitos, su principal problema, al igual que el resto de elementos de su grupo terap\u00e9utico (bencimidazol carbamatos), es su baja solubilidad, lo que condiciona su absorci\u00f3n y por lo tanto su biodisponibilidad. La utilizaci\u00f3n de recursos tecnol\u00f3gicos puede mejorar su solubilidad y este ha sido el objetivo de nuestro trabajo, al incluir el albendazol en complejos de hidroxipropil-beta-ciclodextrina. La preparaci\u00f3n de estos complejos de inclusi\u00f3n permite mejorar significativamente biodisponibilidad del f\u00e1rmaco e incrementar su eficacia antihelm\u00edntica. Utilizando un modelo murino de trichinella, hemos podido comprobar un aumento significativo de la eficacia en las fases intestinal y muscular. El estudio de los par\u00e1metros farmacocin\u00e9ticos nos ha permitido, adem\u00e1s, analizar la evoluci\u00f3n que los enanti\u00f3meros del ricobendazol, metabolito activo del albendazol, tienen tanto en el hospedador como en el par\u00e1sito y validar cual de estos enentioomeros es el principal responsable de la acci\u00f3n terap\u00e9utica. La presencia de par\u00e1sitos en el intestino es un factor tambi\u00e9n a tener en cuenta, a la hora de evaluar la biodisponibilidad de f\u00e1rmacos administrados por v\u00eda oral, ya que pueden producir procesos inflamatorios que modifiquen las condiciones del hospedador y la abosorci\u00f3n de las sustancias administradas. En este trabajo tambi\u00e9n se ha evaluado la incidencia que la presencia de trichinella spiralis en el intestino tiene en la absorci\u00f3n y biodisponbilidad del albendazol.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio biofarmac\u00e9utico y paraistol\u00f3gico de una formulaci\u00f3n de albendazol en hidroxipropil-beta-ciclodextrina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio biofarmac\u00e9utico y paraistol\u00f3gico de una formulaci\u00f3n de albendazol en hidroxipropil-beta-ciclodextrina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Jos\u00e9 Garc\u00eda Rodr\u00edguez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/04\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Bolas Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio  r. Mart\u00ednez fern\u00e1ndez <\/li>\n<li>gracia Merino pel\u00e1ez (vocal)<\/li>\n<li>Francisco Antonio Rojo vazquez (vocal)<\/li>\n<li>M\u00aa Jes\u00fas Perteguer prieto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Jos\u00e9 Garc\u00eda Rodr\u00edguez El abendazol es un antihelm\u00edntico de amplio espectro utilizado en el tratamiento de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[108097,3216,22350,58313,141387,141388],"class_list":["post-64057","post","type-post","status-publish","format-standard","hentry","category-sin-categoria","tag-antonio-r-Martinez-fernandez","tag-francisco-antonio-rojo-vazquez","tag-francisco-bolas-fernandez","tag-gracia-merino-pelaez","tag-juan-jose-garcia-rodriguez","tag-ma-jesus-perteguer-prieto"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/64057","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=64057"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/64057\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=64057"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=64057"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=64057"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}