{"id":64106,"date":"2018-03-09T22:52:08","date_gmt":"2018-03-09T22:52:08","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-las-p38map-kinasas-en-la-miogenesis-y-la-regeneracion-muscular\/"},"modified":"2018-03-09T22:52:08","modified_gmt":"2018-03-09T22:52:08","slug":"papel-de-las-p38map-kinasas-en-la-miogenesis-y-la-regeneracion-muscular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/papel-de-las-p38map-kinasas-en-la-miogenesis-y-la-regeneracion-muscular\/","title":{"rendered":"Papel de las p38map kinasas en la miog\u00e9nesis y la regeneraci\u00f3n muscular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Vanesa Ruiz Bonilla <\/strong><\/h2>\n<p>La v\u00eda de se\u00f1alizaci\u00f3n de p38 map kinasa (mitogen activated protein kinase) presenta un papel fundamental en la diferenciaci\u00f3n muscular. No obstante, la contribuci\u00f3n relativa de cada una de las 4 isoformas de p38 mapk (p38a, p38b, p38g y p38d) en la miog\u00e9nesis se desconoce. En esta tesis demostramos que mioblastos carentes en p38a, pero no en p38b y p38d, son incapaces de diferenciarse y formar miotubos multinucleados, mientras que mioblastos carentes en p38g presentan una capacidad de fusi\u00f3n reducida. Mostramos que el defecto miog\u00e9nico observado en mioblastos p38ad\/d es debido a un retraso en la salida del ciclo celular y una continua proliferaci\u00f3n en condiciones de diferenciaci\u00f3n. La activaci\u00f3n de la v\u00eda jnk\/cjun se encuentra incrementada en mioblastos p38ad\/d, induciendo un incremento en la expresi\u00f3n de ciclina d1; adem\u00e1s, la inhibici\u00f3n de la actividad de jnk rescata el fenotipo proliferativo. Con todo ello concluimos que p38a regula negativamente la activaci\u00f3n de jnk previamente a su efecto sobre la transcripci\u00f3n de genes m\u00fasculo-espec\u00edficos en mioblastos primarios. Los estudios realizados en m\u00fasculo esquel\u00e9tico de ratones neonatales deficientes en cada una de las distintas isoformas de p38, muestran que \u00fanicamente la deleci\u00f3n de p38a induce un fenotipo muscular, observ\u00e1ndose una hiperproliferaci\u00f3n y un retraso en la maduraci\u00f3n celular. Adem\u00e1s, los estudios realizados en m\u00fasculo esquel\u00e9tico adulto de ratones deficientes en p38b, p38g y p38d no presentan una alteraci\u00f3n en estado basal o tras la inducci\u00f3n de un proceso de regeneraci\u00f3n muscular. Los estudios realizados con diferentes modelos de ratones carentes de p38a en m\u00fasculo esquel\u00e9tico adulto no muestran un papel de p38a en la miog\u00e9nesis tard\u00eda, no obstante este punto ha de ser analizado con mayor detenimiento.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de las p38map kinasas en la miog\u00e9nesis y la regeneraci\u00f3n muscular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de las p38map kinasas en la miog\u00e9nesis y la regeneraci\u00f3n muscular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Vanesa Ruiz Bonilla <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pompeu fabra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/04\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pura Mu\u00f1oz C\u00e1novas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  lourdes Arbon\u00e9s de rafael <\/li>\n<li>m\u00f3nica Zamora villafaina (vocal)<\/li>\n<li>m\u00f3nica Suelves esteban (vocal)<\/li>\n<li>roser L\u00f3pez alemany (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vanesa Ruiz Bonilla La v\u00eda de se\u00f1alizaci\u00f3n de p38 map kinasa (mitogen activated protein kinase) presenta un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[849,35,18712],"tags":[87156,141491,141490,119307,99535,141489],"class_list":["post-64106","post","type-post","status-publish","format-standard","hentry","category-biologia-celular","category-ciencias-de-la-vida","category-pompeu-fabra","tag-maria-lourdes-arbones-de-rafael","tag-monica-suelves-esteban","tag-monica-zamora-villafaina","tag-pura-munoz-canovas","tag-roser-lopez-alemany","tag-vanesa-ruiz-bonilla"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/64106","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=64106"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/64106\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=64106"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=64106"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=64106"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}