{"id":64190,"date":"2018-03-09T22:52:11","date_gmt":"2018-03-09T22:52:11","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/opioide-hartzaileak-delta-kappa-mu-eta-kannabinoide-hartzaileak-cb1-cb2-giza-espermatozoideetan-espresatzen-dira-eta-haien-mugikortasunean-eragiten-dute\/"},"modified":"2018-03-09T22:52:11","modified_gmt":"2018-03-09T22:52:11","slug":"opioide-hartzaileak-delta-kappa-mu-eta-kannabinoide-hartzaileak-cb1-cb2-giza-espermatozoideetan-espresatzen-dira-eta-haien-mugikortasunean-eragiten-dute","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/farmacologia-molecular\/opioide-hartzaileak-delta-kappa-mu-eta-kannabinoide-hartzaileak-cb1-cb2-giza-espermatozoideetan-espresatzen-dira-eta-haien-mugikortasunean-eragiten-dute\/","title":{"rendered":"Opioide-hartzaileak (delta, kappa, mu) eta kannabinoide-hartzaileak (cb1, cb2) giza espermatozoideetan espresatzen dira eta haien mugikortasunean eragiten dute"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ekaitz Agirregoitia Marcos <\/strong><\/h2>\n<p>Giza espermatozoideek ernalketa burutu ahal izateko, hainbat aldaketa fisiol\u00f3gico pairatu behan dituzte. Aldaketa horietatik asko, mintz plasmatikoko hartzaileek gidatutako komunikazioagatik gertatzen dira.  zentzu horretan, sistema opioidearen eta kannabinoidearen hartkaileen presentzia giza espermatozoideetan aztertu zen. Bigarrenik, hartzaile hajek antzematean, hartzaile mota bakoitzaren aktibazioaren eragina espermatozoideen mugikortasunean aztertu genuen.  rt-pcr, inmunoblotting eta mikroskopia konfokal bidezko inmuinozotokimika erabiliz, giza espermatozoideetan 3 opioide-hartzaileen (delta, kappa eta mu) eta 2 kannabinoide-hartzaileen (cb1 eta cb2) presentzia baieztatu genuen. giza hazia agonista eta antagonista opioideekin eta kannabinoideekin inkubatu ostean, hauxe ikusi genuen besteak beste: mu-hartzailearen agonistak (morfina 10 elevado a 7 m), delta-hartzailearen antagonistak (naltrindol 10 elevado -4 m) eta cb1 hastzailearen agonistak (acea 10 elevado -5 m) espermatozoide ez-mugikorren portzentaia igo zuten. Cb2 hartzailearen agonistak (jwh-015 10 elevado -5 m) mugikortasun progresibo azkarra gutxitu zuen. Azkenik, kappa-hartzailearen aktibazioak ez zuen mugikortasunean eraginik izan.  las honen aurkikuntsek, gizonezkoen ernaltze-prozesuan, opioide-hartzaileek zein kannabiniode-hartzaileek duten garantiza ezagutaraztea ahalbidetu dute eta hainbat patologien diagnostiko eta tratamendurako atea ireki dezakete epe luze\/ertain batean.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Opioide-hartzaileak (delta, kappa, mu) eta kannabinoide-hartzaileak (cb1, cb2) giza espermatozoideetan espresatzen dira eta haien mugikortasunean eragiten dute<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Opioide-hartzaileak (delta, kappa, mu) eta kannabinoide-hartzaileak (cb1, cb2) giza espermatozoideetan espresatzen dira eta haien mugikortasunean eragiten dute <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ekaitz Agirregoitia Marcos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/04\/2008<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jon Irazusta Astiazaran<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miren Cajaraville bereziartua <\/li>\n<li>arkaitz Carracedo puchalt (vocal)<\/li>\n<li>nicolas Garrido puchalt (vocal)<\/li>\n<li>joseba Pineada ortiz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ekaitz Agirregoitia Marcos Giza espermatozoideek ernalketa burutu ahal izateko, hainbat aldaketa fisiol\u00f3gico pairatu behan dituzte. Aldaketa horietatik [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[561,17971,12909],"tags":[141655,141653,72633,141656,141654,47459],"class_list":["post-64190","post","type-post","status-publish","format-standard","hentry","category-farmacologia-molecular","category-fisiologia-de-la-respiracion","category-pais-vasco-euskal-herriko-unibertsitatea","tag-arkaitz-carracedo-puchalt","tag-ekaitz-agirregoitia-marcos","tag-jon-irazusta-astiazaran","tag-joseba-pineada-ortiz","tag-miren-cajaraville-bereziartua","tag-nicolas-garrido-puchalt"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/64190","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=64190"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/64190\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=64190"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=64190"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=64190"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}